LRRC32 (DS-1055 Biosimilar) Recombinant Monoclonal Antibody

1. GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review] PMID: 27095576
2. Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma. PMID: 27248166
3. High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer. PMID: 26885615
4. study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production. PMID: 28607112
5. GARP plays an important role in the pathogenesis of atopic dermatitis. PMID: 27884290
6. CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
7. these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment PMID: 27913437
8. LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
9. GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction. PMID: 26357016
10. since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb PMID: 26584734
11. GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PMID: 24098777
12. we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells PMID: 23650616
13. Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation. PMID: 22278742
14. There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels PMID: 22070912
15. GARP is a key receptor controlling FOXP3 in T(reg) cells following T-cell activation in a positive feedback loop assisted by LGALS3 and LGMN PMID: 19453521
16. the processing and expression of LRRC32 PMID: 21615933
17. on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk PMID: 21907864
18. GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression PMID: 18628982
19. Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes. PMID: 19651619
20. Expression of GARP on activated regulatory T cells correlates with their suppressive capacity. PMID: 19666573
21. Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones. PMID: 19750484

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HGNC: 4161

OMIM: 137207

KEGG: hsa:2615

STRING: 9606.ENSP00000260061

UniGene: Hs.151641