NRP1 (vesencumab Biosimilar) Recombinant Monoclonal Antibody

1. HLA-G, NRP1, and PD-1, may be involved in the immune response in psoriatic patients PMID: 29790686
2. miR-320/NRP-1 axis contributes to the growth and metastasis of cholangiocarcinoma cells. PMID: 28618167
3. we demonstrated that HS3ST3B enhances the proliferation and survival of breast cancer MDA-MB-231 cells, via a mechanism that is dependent on Nrp1. PMID: 30360368
4. The serum NRP1 was significantly associated with AFP, gamma-GT, Alb, bile acid, ALT, AST, ALP and pre-Alb. NRP1 is a novel tumor marker in HCC. PMID: 29966621
5. lnc00152 was aberrantly overexpressed in colorectal tumors and cancer cells and that lnc00152 was modulated by miRNA206. lnc00152 overexpression promoted epithelial-mesenchymal transition and increased neuropilin1 expression in the colorectal cancer cells. PMID: 29956750
6. the results presented herein indicate that NRP1 exerts tumor suppressive effects in NB, at least in part by regulating the expression of beta1 integrin PMID: 29750423
7. NRP1 may be important in the etiology of menstrual migraine. PMID: 29671086
8. clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1. These results indicated that the bone destruction level expanded from days 7 to 35 PMID: 29457037
9. Study demonstrated that NRP1+ cells possess tumor-initiating cells (TIC) properties, including the preferential expression of stemness markers, higher clonogenic and self-renewal potential, and increased cell migration capacity. These findings support an important role for NRP1 in the biology of lung cancer TICs. PMID: 29138851
10. Authors demonstrated that when VEGFR2 was inhibited, NRP-1 appeared to regulate RAD51 expression through the VEGFR2-independent ABL-1 pathway, consequently regulating radiation sensitivity. In addition, the combined inhibition of VEGFR2 and NRP-1 appears to sensitize cancer cells to radiation. PMID: 29777301
11. NRP1, as a promoter of odontoblast differentiation, regulates dental pulp stem cells via the classical Wnt/beta-catenin pathway. PMID: 28910136
12. The new observation that shows strong NP-1 immunoreactivity of these particles, and decreased NP1 expression in syncytiotrophoblast of preeclampsia (PET) placentas in comparison to the control group, may imply a role of NP-1 in PET. PMID: 26937865
13. rs2228638 of NRP1 may have a role in tetralogy of Fallot risk in European and Chinese Han populations PMID: 29432830
14. Data show that neuropilin 1 (NRP1) binds extracellular AGO2 (carrying miRNA or not), and internalizes AGO2/miRNA complexes. PMID: 27486976
15. Data suggest neuropilin-1 (NRP-1) as a therapeutic target to reduce tumor fibrosis and pancreatic ductal adenocarcinoma (PDAC) progression. PMID: 27542226
16. Results suggest that targeting the transmembrane domains (TMD) of neuropilin-1 (NRP1) in breast cancer is a potent new strategy to fight against breast cancer and related metastasis. PMID: 27351129
17. By blocking neuropilin-1 receptor (NRP-1) in tumor-bearing mice, luciferase activity in tumors delivered by HK polyplexes was reduced by 96%, whereas activity in normal tissues was minimally reduced. PMID: 27257039
18. High NRP1 expression is associated with metastasis in triple-negative breast cancer. PMID: 26967387
19. Overexpression of Neuropilin 1 incresed in breast cancer stem cells formation and breast cancer stem cells-induced tube formation and knockdown of Neuropilin 1 reduced CSCs-related traits. PMID: 29179185
20. Nrp1 mediates the migratory behavior of mesangial cells. PMID: 28835419
21. this study identified the NRP1 cytoplasmic domain as essential for acute vascular hyperpermeability induced by different NRP1 ligands: a ligand- blocking antibody against NRP1 and a CendR peptide. PMID: 27117252
22. Data indicate that miR-206 inhibits neuropilin-1 (NRP1) and SMAD2 gene expression by directly binding to their 3'-UTRs. PMID: 27014911
23. Results show that Nrp1 plays a critical role in balancing responsiveness to VEGF-A versus TGFbeta to regulate glioblastoma growth, progression, and recurrence after anti-vascular therapy. PMID: 28938007
24. Data provide evidence that NRP1 functions to enhance the metastatic potential of prostate tumors. PMID: 28092670
25. NRP1 is an important niche component PMID: 27676403
26. our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR signaling in PDA cells. PMID: 26804176
27. Our findings identify aberrant active integrin b1-driven Src-Akt hyperactivation as a primary resistance mechanism to cetuximab in PDAC cells and offer an effective therapeutic strategy to overcome this resistance using an EGFR and NRP1 dual targeting antibody PMID: 27797376
28. VEGF-A acts via interaction with NRP-1 to trigger intracellular events leading to ECS cell survival and formation of aggressive, invasive and highly vascularized tumors. PMID: 26804163
29. These data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1-IFNgamma crosstalk. PMID: 27591257
30. This study indicates that capsaicin application results in significant loss of epidermal NRP-1 receptor expression, whereas diabetic subjects presenting small fiber neuropathy show full epidermal NRP-1 expression in contrast to the basal expression pattern seen in healthy controls PMID: 27598321
31. Study show that a high percentage of intratumoral NRP1(+) Tregs correlates with poor prognosis in melanoma and head and neck squamous cell carcinoma. PMID: 28552348
32. Study revels the structural description of the neuropilin-1 ectopic region by reporting the crystal structure of its MAM domain. The domain adopts a jellyroll fold that is stabilized by a Ca2+ ion while forming a molecular surface that is distinct from its structural homologs. PMID: 27720589
33. Data suggest that neuropilin-1 (NRP1) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (a peptide fragment of NE) in breast cancer cells. PMID: 28468826
34. This report is the first study characterizing the specific functions of NRP1-Delta7, a glycosaminoglycan-defective neuropilin-1 splice variant that displays anti-tumorigenic properties in vitro and in vivo. PMID: 27798666
35. this study shows that NRP1 can act as a co-receptor for PDGF-D-PDGFRbeta signaling and is possibly implicated in intercellular communication in the vascular wall PMID: 28254885
36. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1, with particular focus on neuronal and vascular roles in the brain and retina. PMID: 26923176
37. Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization reduced viability of breast cancer cells. PMID: 27937055
38. Upregulated expression of NRP1 is associated with glioma. PMID: 27481513
39. Studies suggest that the activation of NRP-1 by PlGF directly contributes to tumour aggressiveness and to melanoma escape from anti-VEGF-A therapies. PMID: 26846845
40. REVIEW: Nrp1 functions in the vasculature is critical for the development of targeted therapeutics for cancer and vascular diseases such as atherosclerosis and retinopathies. PMID: 26849476
41. High Expression of Neuropilin-1 Associates with Hepatocellular Carcinoma. PMID: 26563279
42. Increased NRP-1 expression is associated with metastatic endometrial and lung cancers. PMID: 26701889
43. miR-152 suppression in NSCLC cells might promote neuropilin-1 mediated cancer metastasis. PMID: 26823738
44. NRP-1 was found to be overexpressed in gastric cancer (GC) tissues, and its expression correlates with the clinical staging, tumor differentiation and pathological types of gastric cancer. PMID: 26795388
45. NRP1 was targeted by miR130a and miR130b at the binding site of chromosome 10: 334668643466870, which was involved in the axon guidance signaling pathway. PMID: 26573160
46. Semaphorin-3a, neuropilin-1 and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism. PMID: 26602825
47. neuropilin-1 is regulated in the oral epithelium and is selectively up-regulated during epithelial dysplasia PMID: 26877262
48. NRP1 over-expression in miR-365 expressing cells could rescue invasion and growth defects of miR-365. In addition, miR-365 expression inversely correlated with NRP1 protein levels in malignant melanoma PMID: 26406949
49. Data show that binding of pleiotrophin (PTN) to neuropilin-1 (NRP-1) stimulated the internalization and recycling of NRP-1 at the cell surface. PMID: 26408254
50. Study found significant down-regulation of placental NRP-1 expression in fetal growth restriction pregnancies complicated with absent end-diastolic flow in the umbilical artery. PMID: 26409917

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HGNC: 8004

OMIM: 602069

KEGG: hsa:8829

STRING: 9606.ENSP00000265371

UniGene: Hs.131704