NRP1

Neuropilin-1, also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD304, belongs to the neuropilin family. Neuropilins (NRPs) were first discovered by Takagi et al. in frozen sections of nerve tissues of Xenopus laevis by immunofluorescence staining, and confirmed to be a non-tyrosine kinase transmembrane glycoprotein. NRP-1 was first discovered and paid attention to in the NRPs family. NRP-1 is divided into two forms, membrane neuropilin-1 (mNRP-1) and soluble neuropilin-1 (sNRP-1). NRP-1, known to all, usually refers to mNRP-1.

neuropilin 1 acts as a co-receptor for a number of extracellular ligands, including Sema3 (binding to the a1/a2 and part of the b1/b2 domain of the NRP-1), growth factor VEGF-A/B/D/E, placental growth factor 2, HGF, TGF-B1, bFGF and PDGF, (binding to the b1/b2 domain of NRP-1 receptor) and membrane receptors (such as filamentous protein, VEGF receptor, PDGF receptor and TGF receptor, binding to NRP- 1 The b1/b2 and c domains of the receptor). In addition, NRP-1 can interact with other transmembrane proteins such as integrins αvβ3 and β1 to activate a series of signal transfer pathways.

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Popular Product

Recombinant Human Neuropilin-1(NRP1) (Active) (CSB-MP016091HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of NRP1-VEGF165 validated by functional ELISA

Immobilized human VEGF165 (CSB-MP025833HU(F4)) at 2 μg/ml can bind human NRP1, the EC₅₀ is 22.68-34.55 ng/ml.