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SIGLEC15 (NC-318 Biosimilar) Recombinant Monoclonal Antibody

SIGLEC15 (NC-318 Biosimilar) Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA761623MB1HU
Size	US$9799
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q6ZMC9

Target Names

SIGLEC15

Alternative Names

5G-12 research-grade biosimilar; NC 318 research-grade biosimilar ;SIGLEC15 antibody; CD33L3 antibody; Sialic acid-binding Ig-like lectin 15 antibody; Siglec-15 antibody; CD33 antigen-like 3 antibody

Species Reactivity

Human

Immunogen

Recombinant Human SIGLEC15 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to NC-318, targeting SIGLEC15 (Sialic Acid Binding Ig-like Lectin 15), a transmembrane protein that plays critical roles in immune regulation and bone remodeling. SIGLEC15 functions as an immune checkpoint molecule expressed on tumor-associated macrophages and myeloid cells, where it suppresses T cell activation and promotes an immunosuppressive tumor microenvironment. This target has emerged as particularly relevant in oncology research, as SIGLEC15 expression is largely absent in normal tissues but upregulated in various solid tumors, including non-small cell lung cancer, colorectal cancer, and head and neck cancers, making it an attractive therapeutic target distinct from PD-1/PD-L1 pathways.

NC-318 represents a pioneering anti-SIGLEC15 antibody that entered clinical development as a potential cancer immunotherapy agent. This biosimilar antibody provides researchers with a valuable tool for investigating SIGLEC15-mediated immune suppression, exploring combination immunotherapy strategies, and studying macrophage polarization in the tumor microenvironment. It supports investigations into novel immune checkpoint mechanisms and osteoclast biology.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Target Background

Function

Binds sialylated glycoproteins.

Gene References into Functions

Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-beta secretion in TAMs PMID: 23035012

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

Tissue Specificity

Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Database Links

HGNC: 27596

KEGG: hsa:284266

STRING: 9606.ENSP00000374125

UniGene: Hs.287692

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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