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SIGLEC15 (PYX-106 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA761623MB2HU
Size US$9799
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Product Details

Uniprot No.
Q6ZMC9
Target Names
SIGLEC15
Alternative Names
Anti-Siglec-15 monoclonal antibodies(Biosion, Inc.) research-grade biosimilar; Anti-siglec15 monoclonal antibody (Biosion) research-grade biosimilar; BSI060T research-grade biosimilar; BSI 060T research-grade biosimilar; BSI-060T research-grade biosimilar; BSI- 060T research-grade biosimilar; PYX-106 research-grade biosimilar ;SIGLEC15 antibody; CD33L3 antibody; Sialic acid-binding Ig-like lectin 15 antibody; Siglec-15 antibody; CD33 antigen-like 3 antibody
Species Reactivity
Human
Immunogen
Recombinant Human SIGLEC15 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to PYX-106, targeting SIGLEC15 (Sialic Acid-Binding Ig-Like Lectin 15), a transmembrane protein that plays crucial roles in osteoclast differentiation and immune regulation. SIGLEC15 functions independently of RANKL in promoting bone resorption and is expressed on tumor-associated macrophages within the tumor microenvironment, where it mediates immunosuppression by inhibiting T cell activation. This dual functionality implicates SIGLEC15 in both skeletal disorders and cancer immune evasion, making it a compelling therapeutic target for osteoporosis, bone metastases, and various malignancies.

PYX-106, the reference antibody developed by Pioneering Medicines (formerly Pyxis Oncology), is an investigational immunotherapy designed to normalize the tumor immune microenvironment by blocking SIGLEC15-mediated immune suppression. This biosimilar antibody provides researchers with a valuable tool for investigating SIGLEC15 biology, studying immune checkpoint mechanisms distinct from PD-1/PD-L1 pathways, exploring osteoclast function, and evaluating combination immunotherapy strategies in preclinical models of cancer and bone disease.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

SIGLEC15 Antibodies

SIGLEC15 Proteins

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Target Background

Function
Binds sialylated glycoproteins.
Gene References into Functions
  1. Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-beta secretion in TAMs PMID: 23035012
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Tissue Specificity
Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
Database Links

HGNC: 27596

KEGG: hsa:284266

STRING: 9606.ENSP00000374125

UniGene: Hs.287692

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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