STAB1 (Bexmarilimab Biosimilar) Recombinant Monoclonal Antibody

1. Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder PMID: 29442043
2. Systemic rAAV-DCN in neuroblastoma-grafted nude mice inhibited stabilin-1. PMID: 28631095
3. Results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors as a mechanism of stabilin-1 induced tumor growth. PMID: 27105498
4. These data define stabilin-1 as a new immunosuppressive molecule and suggest that stabilin-1(high) monocytes may dampen proinflammatory reactions in vivo. PMID: 26608916
5. The present findings suggest that STAB1 is a new and highly promising candidate gene in this region. The combining of gene expression and GWAS data may provide valuable insights into the biological mechanisms of BD. PMID: 25136889
6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
7. The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. PMID: 21483103
8. macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus PMID: 21480214
9. Studies identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay. PMID: 21308731
10. CLEVER-1/stabilin-1 can support lymphocyte transendothelial migration; it also may provide an organ-specific signal for regulatory T cell recruitment to the inflamed liver and to hepatocellular carcinoma. PMID: 21368224
11. Studies shoe that understanding stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation. PMID: 20953554
12. these results indicate that GULP functions as an adaptor protein for stabilin-1-mediated phagocytosis. PMID: 20599701
13. role in endocytic clearance and secretion in macrophages; review PMID: 19457577
14. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
15. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. PMID: 12077138
16. This and FEEL-2 are endocytic receptors for advanced glycation end products. PMID: 12473645
17. CLEVER-1 also known as stabilin-1 or FEEL-1) is a large multifunctional glycoprotein implicated in scavenging, angiogenesis, cell adhesion and angiogenesis PMID: 15297319
18. role for stabilin-1 as a rapidly recycling scavenger receptor PMID: 15345716
19. stabilin-1 may function in endocytic and secretory processes of human macrophages. PMID: 15345724
20. Stabilin-1 internalizes and targets secreted protein acidic and rich in cysteine (SPARC) to an endosomal pathway in stably transfected Chinese hamster ovary cells. PMID: 16670288
21. Stabilin-1 mediates internalization and endosomal sorting of placental lactogen. PMID: 18292525
22. Stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a phosphatidylserine-dependent manner. PMID: 19726632
23. The novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis. PMID: 19752197

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HGNC: 18628

OMIM: 608560

KEGG: hsa:23166

STRING: 9606.ENSP00000312946

UniGene: Hs.301989