STAB1

The STAB1 gene encodes the protein named Stabilin - 1. Commonly, it is also known as Haverhillia receptor - 1. Stabilin - 1 functions as a scavenger receptor on the surface of sinusoidal endothelial cells. It clears various ligands like advanced glycation end - products and acetylated low - density lipoproteins from the blood.
Stabilin - 1 is involved in the TGF - β signaling pathway. Abnormalities in this protein have been associated with diseases such as liver fibrosis. In the field of drug development, research is underway to target Stabilin - 1 to develop therapies for liver - related disorders and improve the scavenging function of endothelial cells.