TREM1 (ABBV-8736 Biosimilar) Recombinant Monoclonal Antibody

1. These data show that human macrophages infected with human immunodeficiency virus-1 show an increased expression of TREM-1. In parallel, direct exposure to the human immunodeficiency virus-1-related proteins Tat or gp120 induces TREM-1 expression in macrophages and confers anti-apoptotic attributes. PMID: 28181540
2. Current data suggest that sTREM-1 might become a useful biomarker for the prediction of neonatal sepsis; however, the significant variation in the used threshold values (that ranged between 77.5 and 1707.35 pg/ml) and the methodological differences across studies limit the value of our findings in clinical practice.[Review] PMID: 29644420
3. TREM-1 is a predictive biomarker of in-stent restenosis and an important mediator of cellular inflammation, migration, and proliferation in vascular smooth muscle cells PMID: 29080545
4. The present study highlights the role of urine sTREM-1 levels in late-onset sepsis. PMID: 29480083
5. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. PMID: 27762264
6. serum levels seem higher in newly diagnosed type 1 diabetes patients than in their healthy siblings (not statistically significant) PMID: 27862781
7. TREM-1 interventions by means of LP17, LR12 and TREM-1 fusion protein did not ameliorate IR-induced injury. In the human renal transplant cohort, donor and recipient TREM1 gene variant p.Thr25Ser was not associated with DGF, nor with biopsy-proven rejection or death-censored graft failure. We conclude that TREM-1 does not play a major role during experimental renal IR and after kidney transplantation PMID: 27928159
8. TREM-1 plays an important role in mediating platelet activation. PMID: 28837205
9. Serum sTREM-1 level is significantly higher in diarrhea-predominant irritable bowel syndrome (D-IBS) patients and positively correlates with abdominal pain, which may be initiated by TREM-1-associated macrophage activation, indicating the existence of subclinical inflammation in D-IBS. PMID: 29516326
10. TREM-1 overexpression and M1 macrophage polarization are associated with obesity-induced insulin resistance. PMID: 28454543
11. TREM-1 may have a role in pathology of craniopharyngioma and Rathke's cleft cyst PMID: 27409178
12. low expression level of TREM-1 might be a characteristic for tumor-associated macrophages in lung cancer PMID: 27244892
13. The results demonstrate that both commensal and pathogenic oral bacteria activate the TREM-1 pathway, resulting in a proinflammatory TREM-1 activity-dependent increase in proinflammatory cytokine production. PMID: 27448788
14. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. PMID: 28089248
15. In the premature rupture of membranes group,the NF-kappaB p65 and sTREM-1 levels in maternal blood were significantly higher in women with chorioamnionitis than women without chorioamnionitis (P<.05). PMID: 27521929
16. Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation PMID: 28920169
17. findings showed detectable expression of TREM-1 in 100% of samples, urinary tract infection (UTI) and non-UTI groups; levels of sTREM-1 were detected in patients with UTI, but not in non-UTI patients; TREM-1 levels in patients with UTI tend to be higher and are associated with increased neutrophils and cytokine activity induced by bacteria PMID: 28367708
18. The minor allele T of rs2234246 of TERM1 protein, was associated with increased sTREM-1 in the discovery population, explaining 33% of its variance, and with increased levels of mRNA. PMID: 28771614
19. This study provided evidence that rs6910730G, an intronic variant of TREM1, reduced the ability of human monocytes for Abeta phagocytosis, and this reduction was likely attributed to a decreased monocytic TREM1 expression. PMID: 27670763
20. Studies show that bronchoalveolar lavage fluid (BALF) soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels do not discriminate between mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD), in contrast, the interleukin 6 (IL-6)/interleukine 13 (IL-13) ratio measured in BALF effectively differentiated these two diseases. PMID: 28791839
21. study found that soluble TREM-1 is increased and correlates with the clinical and laboratory findings in Crimean Congo Haemorrhagic Fever, a viral infection characterized by activation of inflammation. PMID: 26877157
22. The findings suggest that there are no differences in soluble TREM-1 levels in gingival crevicular fluid between healthy and periodontally diseased elderly adults PMID: 27542376
23. TREM-1 was found to be significantly higher in tissues biopsies and blood of subjects with obesity. Greater expression and activity of TREM-1 suggest a possible role in the underlying pathophysiology of obesity and associated comorbidities. PMID: 28111922
24. This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases. PMID: 27846213
25. Carriage of the TREM1 rs2234237T allele appears to be a risk factor for the development of severe malaria. PMID: 27671831
26. TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis PMID: 27792788
27. is concluded that both HMGB1 and sTREM-1 are released during the inflammatory response of periodontal tissues and they can promote inflammatory process, which leads to tissue destruction. PMID: 27917624
28. The soluble TREM-1 level, core temperature and SAPS II value were the only independent predictors of death after adjustment for potential confounders in sepsis patients admitted to intensive care. PMID: 27729010
29. TREM-1 plays a critical role in osteoarthritis development and IL1B induced chondrocyte injury through regulation of NF-kappaB signaling PMID: 27932245
30. sTREM1 was increased in septic patients with myocardial depression compared to those without myocardial depression. PMID: 27238916
31. this study shows higher levels of TREM-1 in plasma of systemic lupus erythematosus in Egyptian patients PMID: 27648678
32. Increased expression of TREM-1 in S compared to AS patients involving TNFa, MMP-1 and MMP-9 suggest a potential role of TREM-1 in plaque destabilization PMID: 27017522
33. decreased serum level significantly associated with the presence and severity of coronary artery disease; restrains inflammatory reaction in endothelial cells PMID: 27631216
34. Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock. PMID: 27319606
35. This study provides new insights into the possible mechanism of TREM-1 and HIF-1alpha in psoriasis. PMID: 27743451
36. TREM-1 may play an important role in the inflammatory cascade after subarachnoid hemorrhage and act as a monitoring biomarker PMID: 27697433
37. This study shows increased expression of TREM-1 in monocytes from patients with advanced cervical cancer. PMID: 26506490
38. TREM-1 expression is decreased during the generation of human osteoclast precursors PMID: 26852644
39. TREM-1 activation may be involved in the development of Kawasaki disease. PMID: 27324541
40. LPS-induced TREM-1 transcription. PMID: 26397033
41. The study simultaneously evaluated both PCT and soluble TREM-1 along with CRP in febrile patients with autoimmune diseases. PMID: 27096761
42. TREM-1 and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis. PMID: 26963514
43. High TREM-1 expression correlated significantly with increased recurrence in hepatocellular carcinoma. PMID: 25465376
44. Soluble TREM-1 level is significantly increased in hemodialysis patients as are other pro-inflammatory markers. PMID: 26495896
45. TREM-1 is induced by MSU and is associated with the inflammation of human acute gouty arthritis. PMID: 26320130
46. Plasma and urine TREM-1 levels can be used as diagnostic biomarkers for acute kidney injury in critically ill patients with sepsis. PMID: 25944130
47. study found no association between the other investigated SNPs within TREM-1 gene and infective endocarditis risk PMID: 25213166
48. In neonates with late-onset neonatal sepsis, soluble TREM-1 has the potential to provide an excellent predictive value for septic shock/death. PMID: 25461656
49. Soluble TREM-1, a member of the immunoglobulin super-family, is upregulated when neutrophils are exposed to bacteria. PMID: 25294884
50. isolated PMNs have an increased proportion of both TREM1 and DAP12 compared to normal healthy control PMID: 25642940

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HGNC: 17760

OMIM: 605085

KEGG: hsa:54210

STRING: 9606.ENSP00000244709

UniGene: Hs.283022