ALDH1L1 Antibody

1. Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related hepatocellular carcinoma patients PMID: 28714006
2. ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer PMID: 27384481
3. high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients PMID: 27015121
4. The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces. PMID: 28414156
5. The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population. PMID: 26993122
6. Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess of those required for classical one-carbon metabolism. [REVIEW] PMID: 26567272
7. JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1. PMID: 25077544
8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
9. one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke. PMID: 24651765
10. The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues PMID: 21987076
11. Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme. PMID: 21540484
12. These studies support ALDH1L1 as a general CNS astroglial marker. PMID: 21046559
13. inhibition of cell motility by ALDH1L1 associated with dephosphorylation of the actin depolymerizing factor cofilin by PP1 and PP2A PMID: 20729910
14. down-regulation of FDH in tumors is proposed to be one of the cellular mechanisms that enhance proliferation. PMID: 12065246
15. FDH antiproliferative effects on A549 cells include both G(1) cell cycle arrest and caspase-dependent apoptosis PMID: 12805405
16. None of the snps that defined 3 separate haplotype blocks in the FTHFD gene, rs2365004, rs11923466, rs2886059, rs10934751, rs2276731, rs1823213 and rs4646701 were associated with prostate cancer risk. PMID: 19064578

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HGNC: 3978

OMIM: 600249

KEGG: hsa:10840

STRING: 9606.ENSP00000377083

UniGene: Hs.434435