ALDOB Antibody

1. Silencing Aldolase B activated epithelial markers and repressed mesenchymal markers, indicating inactivation of Aldolase B may lead to inhibition of epithelial-mesenchymal transition PMID: 28558381
2. The downregulation of ALDOB could indicate a poor prognosis for HCC patients, and therefore, ALDOB might be considered a prognostic biomarker for HCC, especially at the early stage. PMID: 26376879
3. Single nucleotide polymorphisms in ALDOB, MAP3K1, and MEF2C are associated with cataract. PMID: 25352737
4. both of exogenous and endogenous ALDOB proteins bind to hepatitis B surface antigen and colocalize in the cytoplasm in vitro and inhibit apoptosis of cisplatin-induced HepG2 cells. PMID: 25072145
5. Efficient inhibition of aldolase B can prevent high glucose-induced overproduction of methylglyoxal and related cellular dysfunction in endothelial cells. PMID: 22911800
6. Aldolase B with the A149P substitution has activity that is <100-fold that of the wild type. PMID: 21166391
7. These novel mutations in ALDOB represent 2% of alleles in American HFI (hereditary fructose intolerance) patients, with IVS1+1G>C representing a significantly higher allele frequency (6%) among HFI patients of Hispanic and African-American ethnicity. PMID: 20882353
8. This is the first report of six unrelated patients sharing the same ALDOB deletion, thus indicating a founder effect for this allele. PMID: 20848650
9. Biochemical study of defective aldolase B enzymes is key to revealing the molecular basis of the disease and providing a stronger basis for improved treatment and diagnosis PMID: 20162364
10. Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance. PMID: 12417303
11. The enzyme's structure and function is investigated as a function of temperature.The implications of these structural alterations are discussed with regard to the HFI disease PMID: 12464284
12. expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues PMID: 14966907
13. six new aldolase B mutations in seven unrelated hereditary fructose intolerant (HFI) Italian patients PMID: 15532022
14. Based on these data and after correction for less common and private ALDOB mutations, hereditary fructose intolerance (HFI) prevalence in central Europe is estimated to be 1:26,100 (95% confidence interval 1: 12,600-79,000). PMID: 15880727
15. Reverse-hybridization assay tested for an accurate and robust screening tool to identify common ALDOB mutations. PMID: 17292585
16. Usefulness of ALDOB mutation in screening for diagnosis of hereditary fructose intolerance. PMID: 17457694
17. there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase in the regulation of the proton pump PMID: 17576770
18. Hereditary fructose intolerance with the mutation c.479_482 del AACA PMID: 17955389
19. Sixteen different mutations of the aldolase B (ALDOB) gene were identified in hereditary fructose intolerance patients. PMID: 18541450
20. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007

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HGNC: 417

OMIM: 229600

KEGG: hsa:229

STRING: 9606.ENSP00000363988

UniGene: Hs.530274