ALKBH4 Antibody

Code CSB-PA001610GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ALKBH4
Alternative Names
2010004B12Rik antibody; ABH4 antibody; Abj4 antibody; AlkB; alkylation repair homolog 4 (E. coli) antibody; ALKB4_HUMAN antibody; Alkbh4 antibody; Alkylated DNA repair protein alkB homolog 4 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody; FLJ20013 antibody; Probable alpha-ketoglutarate dependent dioxygenase ABH4 antibody; RGD1308608 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ALKBH4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Gene References into Functions
  1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
  2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
  3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
Protein Families
AlkB family
Tissue Specificity
Widely expressed, with highest expression in pancreas, ovary and spleen.
Database Links

HGNC: 21900

OMIM: 613302

KEGG: hsa:54784

STRING: 9606.ENSP00000292566

UniGene: Hs.658598

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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