ALKBH4 Antibody

Code CSB-PA885759LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue
    All lanes: ALKBH4 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 34, 5 kDa
    Observed band size: 34 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA885759LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ALKBH4 Polyclonal antibody
Uniprot No.
Target Names
ALKBH4
Alternative Names
2010004B12Rik antibody; ABH4 antibody; Abj4 antibody; AlkB; alkylation repair homolog 4 (E. coli) antibody; ALKB4_HUMAN antibody; Alkbh4 antibody; Alkylated DNA repair protein alkB homolog 4 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody; FLJ20013 antibody; Probable alpha-ketoglutarate dependent dioxygenase ABH4 antibody; RGD1308608 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 protein (1-115AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ALKBH4 Antibody (Product code: CSB-PA885759LA01HU) is Non-conjugated. For ALKBH4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA885759LB01HU ALKBH4 Antibody, HRP conjugated ELISA
FITC CSB-PA885759LC01HU ALKBH4 Antibody, FITC conjugated
Biotin CSB-PA885759LD01HU ALKBH4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Gene References into Functions
  1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
  2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
  3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
Protein Families
AlkB family
Tissue Specificity
Widely expressed, with highest expression in pancreas, ovary and spleen.
Database Links

HGNC: 21900

OMIM: 613302

KEGG: hsa:54784

STRING: 9606.ENSP00000292566

UniGene: Hs.658598

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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