ALKBH4 Antibody

Datasheet

Code	CSB-PA885759LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue All lanes: ALKBH4 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34, 5 kDa Observed band size: 34 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA885759LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ALKBH4 Polyclonal antibody

Uniprot No.

Q9NXW9

Target Names

ALKBH4

Alternative Names

2010004B12Rik antibody; ABH4 antibody; Abj4 antibody; AlkB; alkylation repair homolog 4 (E. coli) antibody; ALKB4_HUMAN antibody; Alkbh4 antibody; Alkylated DNA repair protein alkB homolog 4 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody; FLJ20013 antibody; Probable alpha-ketoglutarate dependent dioxygenase ABH4 antibody; RGD1308608 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 protein (1-115AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ALKBH4 Antibody (Product code: CSB-PA885759LA01HU) is Non-conjugated. For ALKBH4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA885759LB01HU	ALKBH4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885759LC01HU	ALKBH4 Antibody, FITC conjugated
Biotin	CSB-PA885759LD01HU	ALKBH4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:2000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.

Gene References into Functions

ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655

Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.

Protein Families

AlkB family

Tissue Specificity

Widely expressed, with highest expression in pancreas, ovary and spleen.

Database Links

HGNC: 21900

OMIM: 613302

KEGG: hsa:54784

STRING: 9606.ENSP00000292566

UniGene: Hs.658598

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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