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ANAPC11 Antibody

Datasheet
Code CSB-PA001696GA01HU
Size $600
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Product Details

Uniprot No.
Q9NYG5
Target Names
ANAPC11
Alternative Names
ANAPC 11 antibody; ANAPC11 antibody; Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody; Anaphase promoting complex subunit 11 antibody; Anaphase promoting complex subunit 11 homolog (yeast) antibody; Anaphase promoting complex subunit 11 homolog antibody; Anaphase-promoting complex subunit 11 antibody; Apc 11 antibody; Apc 11p antibody; APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody; APC11 anaphase promoting complex subunit 11 homolog antibody; APC11 antibody; APC11_HUMAN antibody; Apc11p antibody; Cyclosome subunit 11 antibody; Hepatocellular carcinoma associated RING finger protein antibody; Hepatocellular carcinoma-associated RING finger protein antibody; HSPC 214 antibody; HSPC214 antibody; MGC882 antibody; Yeast APC 11 homolog antibody; Yeast APC11 homolog antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ANAPC11
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Gene References into Functions
  1. siRNA targeted against Apc11 could hamper entry into G2/M phase. PMID: 23007976
  2. Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress PMID: 15256223
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
RING-box family
Tissue Specificity
Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
Database Links

HGNC: 14452

OMIM: 614534

KEGG: hsa:51529

UniGene: Hs.534456

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Related pathways
Cell cycle Ubiquitin mediated proteolysis
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