Western blot
All lanes: ANKS1B antibody at 5.28µg/ml
Lane 1: 293T whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 139, 49, 58, 53, 52, 86, 48, 41, 29, 45 kDa
Observed band size: 139 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA767207ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA767207ESR2HU at dilution of 1:100
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Lead Time
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Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Gene References into Functions
this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. PMID: 28332719
We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers. PMID: 24479813
AIDA1 PTB domain binds amyloid protein precursorin a similar manner to the X11/Mint PTB domain. PMID: 23799029
Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
It is clear that some single-nucleotide polymorphisms and haplotypes of the EB-1 gene are associated with genetic difference between diabetic patients with and without nephropathy. PMID: 20578947
EB1 recognizes the nucleotide state of tubulin in the microtubule lattice PMID: 19851462
site-specific translocation and evidence of postnatal origin of the t(1;19) fusion in childhood acute lymphoblastic leukemia PMID: 12415113
Evidence pertaining to leukemogenesis by the well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its mechanistic implications are considered. PMID: 12700034
Amyloid beta-protein precursor expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. PMID: 12837293
AbetaPP and the AIDA-1 proteins interact in vitro, in living cells and, endogenously, in leukemia cell lines;AIDA-1 proteins are expressed at high levels in the brain PMID: 15004329
the interaction between AbetaPP and AIDA-1 is regulated by alternative splicing of the AIDA-1 protein PMID: 15347684
specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of E2A-Pbx1 fusion protein chimeric oncogene. PMID: 16386788
The basic nuclear import signal for AIDA-1 is buried at the interface between the two sterile alpha motif domains. PMID: 19666031
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Subcellular Location
Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
Tissue Specificity
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain