ANKS1B Antibody

Code CSB-PA767207ESR2HU
Size US$166
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  • Western blot
    All lanes: ANKS1B antibody at 5.28µg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Lane 3: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 139, 49, 58, 53, 52, 86, 48, 41, 29, 45 kDa
    Observed band size: 139 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA767207ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA767207ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ANKS1B Polyclonal antibody
Uniprot No.
Target Names
ANKS1B
Alternative Names
AIDA antibody; AIDA-1 antibody; Amyloid-beta protein intracellular domain-associated protein 1 antibody; Anks1b antibody; ANKS2 antibody; Ankyrin repeat and sterile alpha motif domain containing 1B antibody; Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody; ANS1B_HUMAN antibody; Cajalin 2 antibody; E2A-PBX1-associated protein antibody; EB-1 antibody; EB1 antibody; MGC26087 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B protein (999-1248AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Gene References into Functions
  1. this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. PMID: 28332719
  2. We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers. PMID: 24479813
  3. AIDA1 PTB domain binds amyloid protein precursorin a similar manner to the X11/Mint PTB domain. PMID: 23799029
  4. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
  5. It is clear that some single-nucleotide polymorphisms and haplotypes of the EB-1 gene are associated with genetic difference between diabetic patients with and without nephropathy. PMID: 20578947
  6. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice PMID: 19851462
  7. site-specific translocation and evidence of postnatal origin of the t(1;19) fusion in childhood acute lymphoblastic leukemia PMID: 12415113
  8. Evidence pertaining to leukemogenesis by the well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its mechanistic implications are considered. PMID: 12700034
  9. Amyloid beta-protein precursor expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. PMID: 12837293
  10. AbetaPP and the AIDA-1 proteins interact in vitro, in living cells and, endogenously, in leukemia cell lines;AIDA-1 proteins are expressed at high levels in the brain PMID: 15004329
  11. the interaction between AbetaPP and AIDA-1 is regulated by alternative splicing of the AIDA-1 protein PMID: 15347684
  12. specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
  13. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of E2A-Pbx1 fusion protein chimeric oncogene. PMID: 16386788
  14. The basic nuclear import signal for AIDA-1 is buried at the interface between the two sterile alpha motif domains. PMID: 19666031

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Subcellular Location
Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
Tissue Specificity
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain
Database Links

HGNC: 24600

OMIM: 607815

KEGG: hsa:56899

STRING: 9606.ENSP00000449629

UniGene: Hs.506458

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