Recombinant Human Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B), partial

Code CSB-YP767207HU
MSDS
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Source Yeast
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Code CSB-EP767207HU
MSDS
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Source E.coli
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Code CSB-EP767207HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP767207HU
MSDS
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Source Baculovirus
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Code CSB-MP767207HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ANKS1B
Uniprot No.
Alternative Names
AIDA; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; ANKS2; Ankyrin repeat and sterile alpha motif domain containing 1B; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; Cajalin 2; E2A-PBX1-associated protein; EB-1; EB1; MGC26087
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Gene References into Functions
  1. this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. PMID: 28332719
  2. We provide the first evidence that ANKS1B expression is down regulated in ccRCC tumors relative to patient-matched normal kidney tissue in smokers. PMID: 24479813
  3. AIDA1 PTB domain binds amyloid protein precursorin a similar manner to the X11/Mint PTB domain. PMID: 23799029
  4. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
  5. It is clear that some single-nucleotide polymorphisms and haplotypes of the EB-1 gene are associated with genetic difference between diabetic patients with and without nephropathy. PMID: 20578947
  6. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice PMID: 19851462
  7. site-specific translocation and evidence of postnatal origin of the t(1;19) fusion in childhood acute lymphoblastic leukemia PMID: 12415113
  8. Evidence pertaining to leukemogenesis by the well-characterized E2A-fusion protein E2A-PBX1 is reviewed and its mechanistic implications are considered. PMID: 12700034
  9. Amyloid beta-protein precursor expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. PMID: 12837293
  10. AbetaPP and the AIDA-1 proteins interact in vitro, in living cells and, endogenously, in leukemia cell lines;AIDA-1 proteins are expressed at high levels in the brain PMID: 15004329
  11. the interaction between AbetaPP and AIDA-1 is regulated by alternative splicing of the AIDA-1 protein PMID: 15347684
  12. specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
  13. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of E2A-Pbx1 fusion protein chimeric oncogene. PMID: 16386788
  14. The basic nuclear import signal for AIDA-1 is buried at the interface between the two sterile alpha motif domains. PMID: 19666031

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Subcellular Location
Cytoplasm.; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
Tissue Specificity
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain
Database Links

HGNC: 24600

OMIM: 607815

KEGG: hsa:56899

STRING: 9606.ENSP00000449629

UniGene: Hs.506458

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