AP3D1 Antibody

Datasheet

Code	CSB-PA001876GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O14617

Target Names

AP3D1

Alternative Names

Adapter-related protein complex 3 subunit delta-1 antibody; adaptor-related protein complex 3, delta 1 subunit antibody; ADTD antibody; AP 3 complex delta subunit antibody; AP-3 complex subunit delta antibody; AP-3 complex subunit delta-1 antibody; ap3d1 antibody; AP3D1_HUMAN antibody; Delta 1 subunit of adaptor-related protein complex 3 antibody; Delta Adaptin antibody; Delta-adaptin antibody; hBLVR antibody; Subunit of putative vesicle coat adaptor complex AP 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human AP3D1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Gene References into Functions

Unexpectedly, no evidence of binding between the N-terminal matrix (MA) domain of HIV-1 Gag and the cellular Adaptor Protein AP-3 (AP-3delta) was observed in these in vitro experiments. PMID: 22705971
The matrix region of HIV-1 Gag interacts directly with the delta subunit of the AP-3 complex, and that this interaction plays an important functional role in particle assembly PMID: 15766529
AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes and that the AP-3 pathway ensures that tyrosinase averts entrapment on internal membranes of forming multivesicular bodies PMID: 16162817
The studies demonstrate a role for AP-3 in HIV replication in a tetraspanin-rich compartment in dendritic cells (DC) and contribute to the elucidation of the trafficking pathways required for DC-T cell transfer of HIV-1 infection. PMID: 18034776

Involvement in disease

Hermansky-Pudlak syndrome 10 (HPS10)

Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Adaptor complexes large subunit family

Tissue Specificity

Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.

Database Links

HGNC: 568

OMIM: 607246

KEGG: hsa:8943

STRING: 9606.ENSP00000344055

UniGene: Hs.512815

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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