APBA1 Antibody

Datasheet

Code	CSB-PA837778
Size	US$166
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Image	Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA837778(APBA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Target Background

Product Details

Uniprot No.

Q02410

Target Names

APBA1

Alternative Names

Adapter protein X11 alpha antibody; Adapter protein X11alpha antibody; Amyloid beta A4 precursor protein-binding family A member 1 antibody; Apba1 antibody; APBA1_HUMAN antibody; Mint 1 antibody; Mint-1 antibody; Neuron specific X11 protein antibody; Neuron-specific X11 protein antibody; Neuronal Munc18 1 interacting protein 1 antibody; Neuronal Munc18-1-interacting protein 1 antibody; UROP11 antibody; x11 antibody; X11alpha antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human APBA1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.

Gene References into Functions

Mint1 causes amyloid precursor protein accumulation in the trans-Golgi network. PMID: 26865271
Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
Mint1 826 bridges APP to the small GTPase PMID: 23737971
an autoinhibitory mechanism in Mint1 is important for regulating APP processing and may provide novel therapies for Alzheimer's disease PMID: 22355143
Transcriptional co-activators Taz and Yap mediate signaling via the amyloid beta protein precursor paralogues APLP1 and APLP2 through interactions with Mint1 and Mint3. PMID: 21178287
Study identified the conserved binding site for the peptide on the CASK calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding. PMID: 21763699
Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis. PMID: 20531236
Methylation of MINT1 was significantly more prevalent in UC-CRC cases compared with controls. PMID: 20160714
ApoEr2 regulates cell movement, and both X11alpha and Reelin enhance this effect. PMID: 19720620
A novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of amyloid precursor protein (APP)-interacting proteins Mint1, Mint2, and Mint3 is reported, with multiple novel interactors for these proteins. PMID: 20016085
Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion. PMID: 12016213
Coexpression of X11alpha with amyloid protein precursor retarded its maturation, prolonged its half-life, and inhibited amyloid protein precursor, Abeta40, and Abeta42 secretion. PMID: 12849748
human X11alpha inhibits Abeta production and deposition in vivo in the brain in transgenic mice harboring a familial Alzheimer's disease mutant APP that produces increased levels of Abeta. PMID: 12970358
Involvement of X11L in the phosphorylation of APP family proteins in cellular stress and suggest that X11L protein may be . PMID: 14970211
X11alpha and X11beta have roles in beta-amyloid precursor protein processing PMID: 15699037
Mediates exocytosis and decreases beta-amyloid peptide formation in Alzheimer disease. PMID: 16413130
Data show that neuronal munc18-1-interacting protein 1 is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. PMID: 18836734

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Only about 5% of the protein is located in the nucleus.; [Isoform 2]: Golgi apparatus.

Tissue Specificity

Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.

Database Links

HGNC: 578

OMIM: 602414

KEGG: hsa:320

STRING: 9606.ENSP00000265381

UniGene: Hs.171939

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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