BLCAP Antibody

Code CSB-PA006743
Size US$119
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Product Details

Uniprot No.
Target Names
BLCAP
Alternative Names
BLCAP; BC10; Bladder cancer-associated protein; Bladder cancer 10 kDa protein; Bc10
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Bc10.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IF, ELISA
Recommended Dilution
Application Recommended Dilution
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
Gene References into Functions
  1. Upregulated miR-9-3p has a positive role in human MTC progression by regulating the growth and apoptosis of cancer cells via targeting BLCAP. PMID: 27938505
  2. Our findings reveal that A-to-I RNA editing events alter the genetically coded amino acid in BLCAP YXXQ motif, which drive the progression of cervical carcinogenesis through regulating STAT3 signaling pathway. PMID: 28455960
  3. data indicates that Blcap is a novel Stat3 interaction partner and suggests a role for Blcap in the Stat3-mediated progression of precancerous lesions to invasive tumors of the bladder PMID: 29190807
  4. the functional association of BLCAP and Rb1 might play important roles in proliferation and apoptosis of HeLa cells. PMID: 26986503
  5. Data show that the RNA-edited bladder cancer associated protein (BLCAP) gene may stably promote cell proliferation. PMID: 25499081
  6. Immunoexpression analysis and prognostic value of BLCAP in breast cancer PMID: 23049907
  7. observed a general decrease in BLCAP-editing level in astrocytomas, bladder cancer and colorectal cancer when compared with the related normal tissues PMID: 19908260
  8. Data show that loss of BLCAP expression is associated with tumor progression. PMID: 19783793
  9. might be a potential tumor suppressor gene in cervical carcinoma. PMID: 16675915
  10. BLCAP may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of p53 and NF-kappaB. PMID: 17031575
  11. Blcap is imprinted in mouse and human brain, but not in other mouse tissues. PMID: 18836209

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
BLCAP family
Tissue Specificity
Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
Database Links

HGNC: 1055

OMIM: 613110

KEGG: hsa:10904

STRING: 9606.ENSP00000362637

UniGene: Hs.472651

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