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BLOC1S1 Antibody

Datasheet
Code CSB-PA00495A0Rb
Size US$166
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Image
  • Western Blot
    Positive WB detected in: 293 whole cell lysate(30µg), U87 whole cell lysate(30µg), HeLa whole cell lysate(30µg), MCF7 whole cell lysate(30µg), HL60 whole cell lysate(30µg), THP-1 whole cell lysate(30µg),JK whole cell lysate(30µg),Mouse Brain tissue lysate(30µg),Rat Brain tissue lysate(30µg)
    All lanes: BLOC1S1 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/40000 dilution
    Predicted band size: 17/14 kDa
    Observed band size: 17 kDa
    Exposure time: 1s
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BLOC1S1 Polyclonal antibody
Uniprot No.
P78537
Target Names
BLOC1S1
Alternative Names
BLOC1S1 antibody; BLOS1 antibody; GCN5L1 antibody; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody; BLOC-1 subunit 1 antibody; GCN5-like protein 1 antibody; Protein RT14 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human BLOC1S1
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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BLOC1S1 Antibodies

BLOC1S1 Proteins

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Target Background

Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
Gene References into Functions
  1. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
  2. BLOS1 interacts with KXD1. PMID: 22554196
  3. GCN5L1 interacts with and promotes acetylation of SIRT3 respiratory chain targets and reverses global SIRT3 effects on mitochondrial protein acetylation, respiration and bioenergetics PMID: 22309213
  4. Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID: 22423091
  5. GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria. PMID: 22309213
  6. Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. PMID: 17618940
  7. Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts. PMID: 19246570
  8. Biogenesis of Lysosome-related Organelles complex-1 (BLOC-1) subunit 1 (BLOS1). PMID: 15102850

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Subcellular Location
Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
Protein Families
BLOC1S1 family
Database Links

HGNC: 4200

OMIM: 601444

KEGG: hsa:2647

STRING: 9606.ENSP00000447537

UniGene: Hs.600940

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