BLOC1S1 Antibody

Code CSB-PA002718GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
BLOC1S1
Alternative Names
BLOC1S1 antibody; BLOS1 antibody; GCN5L1 antibody; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody; BLOC-1 subunit 1 antibody; GCN5-like protein 1 antibody; Protein RT14 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human BLOC1S1-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
Gene References into Functions
  1. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
  2. BLOS1 interacts with KXD1. PMID: 22554196
  3. GCN5L1 interacts with and promotes acetylation of SIRT3 respiratory chain targets and reverses global SIRT3 effects on mitochondrial protein acetylation, respiration and bioenergetics PMID: 22309213
  4. Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID: 22423091
  5. GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria. PMID: 22309213
  6. Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. PMID: 17618940
  7. Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts. PMID: 19246570
  8. Biogenesis of Lysosome-related Organelles complex-1 (BLOC-1) subunit 1 (BLOS1). PMID: 15102850

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Subcellular Location
Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
Protein Families
BLOC1S1 family
Database Links

HGNC: 4200

OMIM: 601444

KEGG: hsa:2647

STRING: 9606.ENSP00000447537

UniGene: Hs.600940

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