BNIP2 Antibody

1. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
2. BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain. PMID: 25378581
3. Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2. PMID: 21130087
4. Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing. PMID: 20704564
5. Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells PMID: 11744098
6. BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1 PMID: 12944407
7. BNIP-2 in vivo induces cell dynamics by recruiting Cdc42 PMID: 15652341
8. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507

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HGNC: 1083

OMIM: 603292

KEGG: hsa:663

STRING: 9606.ENSP00000267859

UniGene: Hs.592515