BNIP2 Antibody

Datasheet

Code	CSB-PA001039
Size	US$119
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Image	Western Blot analysis of K562 cells using BNIP-2 Polyclonal Antibody Western Blot analysis of various cells using BNIP-2 Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q12982

Target Names

BNIP2

Alternative Names

BCL2/adenovirus E1B 19 kDa protein interacting protein 2 antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 antibody; BCL2/adenovirus E1B 19kDa interacting protein 2 antibody; BNIP 2 antibody; Bnip2 antibody; BNIP2_HUMAN antibody; NIP2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human BNIP-2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Gene References into Functions

BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain. PMID: 25378581
Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2. PMID: 21130087
Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing. PMID: 20704564
Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells PMID: 11744098
BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1 PMID: 12944407
BNIP-2 in vivo induces cell dynamics by recruiting Cdc42 PMID: 15652341
Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.

Database Links

HGNC: 1083

OMIM: 603292

KEGG: hsa:663

STRING: 9606.ENSP00000267859

UniGene: Hs.592515

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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