CADM4 Antibody

1. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas PMID: 28561015
2. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
3. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2. PMID: 28601637
4. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 PMID: 25893857
5. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly PMID: 23611113
6. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. PMID: 23559354
7. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane. PMID: 23825401
8. CADM4, as well as 4.1B is expressed specifically in human proximal tubules. PMID: 21544807
9. Nec- 4 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
10. TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer. PMID: 16261159

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HGNC: 30825

OMIM: 609744

KEGG: hsa:199731

STRING: 9606.ENSP00000222374

UniGene: Hs.370984