CBX8 Antibody

Code CSB-PA864026ESR2HU
Size US$166
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Image
  • Western blot
    All lanes: CBX8 antibody at 2μg/ml + Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 43 kDa
    Observed band size: 43 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA864026ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA864026ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA864026ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CBX8 Polyclonal antibody
Uniprot No.
Target Names
CBX8
Alternative Names
Cbx8 antibody; CBX8_HUMAN antibody; Chromobox Homolog 8 (Drosophila Pc Class) antibody; Chromobox Homolog 8 (Pc Class Homolog; Drosophila) antibody; Chromobox Homolog 8 antibody; Chromobox protein homolog 8 antibody; hPc3 antibody; Pc Class 3 Homolog (Drosophila) antibody; Pc Class 3 Homolog antibody; Pc3 antibody; Polycomb 3 antibody; Polycomb 3 homolog antibody; RC1 antibody; Rectachrome 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Chromobox protein homolog 8 protein (80-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Gene References into Functions
  1. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
  2. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
  3. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
  4. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
  5. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
  6. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
  7. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
  8. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
  9. Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
  10. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
  11. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
  12. Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
  13. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
  14. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
  15. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741

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Subcellular Location
Nucleus.
Database Links

HGNC: 15962

OMIM: 617354

KEGG: hsa:57332

STRING: 9606.ENSP00000269385

UniGene: Hs.387258

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