CCDC66 Antibody

Datasheet

Code	CSB-PA004728LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA004728LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCDC66 Polyclonal antibody

Uniprot No.

A2RUB6

Target Names

CCDC66

Alternative Names

CCD66_HUMAN antibody; Ccdc66 antibody; Coiled coil domain containing 66 antibody; Coiled coil domain containing protein 66 antibody; Coiled-coil domain-containing protein 66 antibody; DKFZp686C0433 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Coiled-coil domain-containing protein 66 protein (87-286AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCDC66 Antibody (Product code: CSB-PA004728LA01HU) is Non-conjugated. For CCDC66 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004728LB01HU	CCDC66 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004728LC01HU	CCDC66 Antibody, FITC conjugated
Biotin	CSB-PA004728LD01HU	CCDC66 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Plays a role in retina morphogenesis and/or homeostasis.

Gene References into Functions

Results associate a distinct retinal dystrophy phenotype with nicotinamide-nucleotide adenylyltransferase 1 protein (NMNAT1) mutation and suggest coiled-coil domain containing 66 (CCDC66) should not be considered a retinal dystrophy candidate gene. PMID: 28369829
In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively. Taken together, these findings highlight a novel oncogenic function of circRNA in cancer progression and metastasis. PMID: 28249903
this study identifies CCDC66 as a targeting factor for centrosome and cilium proteins PMID: 28235840
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.

Tissue Specificity

Widely expressed (at protein level). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level).

Database Links

HGNC: 27709

KEGG: hsa:285331

STRING: 9606.ENSP00000378167

UniGene: Hs.476399

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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