CDCA3 Antibody

Code CSB-PA001515
Size US$100
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  • Western Blot analysis of HepG2 cells using CdcA3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CDCA3
Alternative Names
CDCA3 antibody; C8 antibody; GRCC8 antibody; TOME1Cell division cycle-associated protein 3 antibody; Gene-rich cluster protein C8 antibody; Trigger of mitotic entry protein 1 antibody; TOME-1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human CdcA3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.
Gene References into Functions
  1. these results define a tumor-supportive role for CDCA3. PMID: 29627567
  2. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). PMID: 29439669
  3. OY-TES-1 downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3. PMID: 25673160
  4. High CDCA3 expression is associated with neoplasms. PMID: 25236463
  5. HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. PMID: 23219899
  6. overexpression of CDCA3 occurs frequently during oral carcinogenesis. PMID: 22839099
  7. a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1 PMID: 15733861

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Subcellular Location
Cytoplasm, cytosol.
Database Links

HGNC: 14624

OMIM: 607749

KEGG: hsa:83461

STRING: 9606.ENSP00000442068

UniGene: Hs.524216

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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