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Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release.
Gene References into Functions
CPAP regulates delivery of its bound beta-tubulin to define the size of microtubule-based cellular structures using a "clutch-like" mechanism. PMID: 27306797
Data suggest that alcohol/ethanol exposure diminishes pool of proliferative neurons (Neuro2a cell line) through disordering of spindle orientation and promotion of asymmetric cell division; these neuronal abnormalities appear to be due to reduced CENPJ protein expression level. PMID: 29778912
CPAP-S467D protein has a low affinity for microtubule binding but a high affinity for pericentriolar material proteins. PMID: 26997271
CPAP promotes timely cilium disassembly to maintain neural progenitor pool. CPAP mutation causes Seckel syndrome with microcephaly. PMID: 26929011
Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of CENPJ has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW] PMID: 26517891
Centrobin plays a role in the stability and centriole elongation function of CPAP and limits the centriole length. PMID: 25616662
studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP-STIL interaction constitutes a conserved key step in centriole biogenesis PMID: 24052813
The results showed a human-specific hypomethylation in the 5' UTR of CENPJ in the brain, where methylation levels among humans are only about one-third of those found among nonhuman primates. PMID: 24288161
Centrobin-CPAP interaction is critical for the recruitment of CPAP to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP on preexisting mother centrioles. PMID: 24700465
CPAP depletion results in asymmetric spindle poles with uneven distribution of pericentriolar material. PMID: 24491538
Sas-4 acts as a vehicle to tether PCM complexes to centrioles independent of its well-known role in centriole duplication PMID: 24385583
CEP120 associates with SPICE1 and CPAP, and depletion of any of these proteins results in short procentrioles. Furthermore, CEP120 or CPAP overexpression results in excessive centriole elongation, a process dependent on CEP120, SPICE1, and CPAP. PMID: 23810536
SUMOylated CPAP could synergistically increase the HBx-induced NF-kappaB activity PMID: 23369793
CEP120 is a CPAP-interacting protein that positively regulates centriole elongation. PMID: 23857771
Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1. PMID: 22699936
STIL and CPAP are essential for centriole formation and for proper spindle position. PMID: 22100914
Results suggest that Cep152 recruits Plk4 and CPAP to the centrosome to ensure a faithful centrosome duplication process. PMID: 21059844
Data establishes that mutation of CENPJ can lead to Seckel syndrome and calls for further investigation of the role played by other microcephaly related genes in the pathogenesis of PD. PMID: 20522431
Results identify centrosomal P4.1-associated protein (CPAP), a human homologue of SAS-4, as a substrate of PLK2 whose activity oscillates during the cell cycle. PMID: 20531387
cell cycle-regulated phosphorylation orchestrates the dynamics of CPAP molecular interaction and centrosome splitting to ensure genomic stability in cell division PMID: 19889632
CPAP was found to augment Stat5-mediated transcription PMID: 12198240
CPAP carries a novel microtubule-destabilizing motif that not only inhibits microtubule nucleation from the centrosome but also depolymerizes taxol-stabilized microtubules. PMID: 15047868
CPAP functions as a coactivator of NF-kappaB-mediated transcription PMID: 15687488
Mutations in CENPJ gene is associated with autosomal recessive primary microcephaly PMID: 15793586
Together, our results reveal a structural role for CPAP to maintain centrosome integrity and normal spindle morphology during cell division. PMID: 16316625
In summary, our results show a direct interaction between CPAP and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent. PMID: 16516142
discuss CENPJ, which similarly exhibits higher rate of protein evolution in primates as compared to rodents and carnivores PMID: 16631324
High levels of LIP1 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role. PMID: 18162190
Mutations in this conserved sequence also eliminate d-SAS-4's microtubule-destabilizing activity, suggesting that d-SAS-4 and CPAP may play similar roles within cells. PMID: 18586240
the PN2-3 fragment of CPAP as a protein with an unprecedented tubulin sequestering mechanism distinct from that of stathmin family proteins. PMID: 19131341
Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. PMID: 19481458
Data show that the CPAP is required for centrosome duplication in cycling human cells, and that CPAP overexpression results in the formation of abnormally long centrioles. PMID: 19481460
Results suggest that CPAP is a new regulator of centriole length and its intrinsic tubulin-dimer binding activity is required for procentriole elongation. PMID: 19503075
Identifies CENPJ as LYST-interacting proteins LIP1 and LIP7, which interact with the lysosomal trafficking regulator (LYST) protein. PMID: 11984006