CEP192 Antibody

1. Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion. PMID: 27562453
2. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. PMID: 28188792
3. Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin. PMID: 24971877
4. Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192. PMID: 26012549
5. Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly. PMID: 25042804
6. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer. PMID: 24997597
7. Loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. PMID: 24277814
8. cooperation between Cep192 and Cep152 is crucial for centriole recruitment of Plk4 and centriole duplication during the cell cycle. PMID: 23641073
9. By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. PMID: 23932902
10. CEP192 promotes robust mitotic spindle assembly by regulating K63-polyubiquitin-mediated signaling through CYLD. PMID: 22895009
11. Cep192-mediated mechanism maximizes AurA activity at centrosomes and appears essential for the function of these organelles as primary microtubule -organizing centers. PMID: 21097701
12. Cep192 stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. PMID: 17980596
13. major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells PMID: 18207742

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HGNC: 25515

OMIM: 616426

KEGG: hsa:55125

STRING: 9606.ENSP00000427550

UniGene: Hs.100914