CERK Antibody

1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway. PMID: 25164007
2. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line. PMID: 22579669
3. TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity. PMID: 22230689
4. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells. PMID: 21621503
5. We have identified a differential role for ceramide kinase in mast-cell activation PMID: 21255156
6. Molecular cloning and functional characterization PMID: 11956206
7. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids PMID: 12855693
8. CERK translocates during activation from the cytosol to a lipid raft fraction PMID: 15899891
9. Pleckstrin homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity. PMID: 16081073
10. sphingoid chain was also required for substrate recognition by CERK PMID: 16170208
11. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain. PMID: 16269826
12. CERK-pleckstrin homology domain plays a crucial role in plasma membrane targeting through its binding to phosphatidylinositol 4,5-bisphosphate and subsequent induction of ceramide-1-phosphate production in the vicinity of the membrane. PMID: 16488390
13. These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants. PMID: 17274985
14. Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT. PMID: 17392267
15. HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation. PMID: 17957442
16. higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK PMID: 18156590
17. identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function PMID: 18662741
18. ceramide kinase, was associated with poor pathohistological grading in breast cancer PMID: 19125296
19. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation. PMID: 19501188
20. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2 PMID: 19778898

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HGNC: 19256

OMIM: 610307

KEGG: hsa:64781

STRING: 9606.ENSP00000216264

UniGene: Hs.200668