CFC1 Antibody

Datasheet

Code	CSB-PA120126
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA120126(CFC1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA120126(CFC1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue, Primary antibody: CSB-PA120126(CFC1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

P0CG37

Target Names

CFC1

Alternative Names

CFC 1 antibody; CFC1 antibody; CFC1_HUMAN antibody; CFC1B antibody; CR 1 antibody; Cripto 1 antibody; Cripto FRL 1 cryptic family 1 antibody; CRYPTIC antibody; Cryptic family 1 antibody; Cryptic family protein 1 antibody; Cryptic gene antibody; Cryptic protein antibody; DTGA2 antibody; FLJ77897 antibody; FRL 1 antibody; Heterotaxy 2 (autosomal dominant) antibody; HTX2 antibody; MGC133213 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human CFC1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:20-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.

Gene References into Functions

The knockdown and overexpression of CFC1 were performed using a lentiviral system in NB cell lines. The overexpression of CFC1 increased sphere formation, cell growth, and colony formation. PMID: 28620148
Results demonstrated that over expression of Snail suppresses Cryptic expression and confirmed that Snail directly binds to Cryptic gene promoter and regulates its expression. PMID: 27793090
enhances macrophage phagocytic activity and upregulates the production of anti- and pro-inflammatory cytokines via the NF-kappaB signaling pathway PMID: 26476731
Data indicate that the duplication and deletion of CFC1 protein may play key roles in the occurrence of heterotaxy syndrome. PMID: 25423076
CFC1 may be involved in the etiology of non-syndromic congenital heart disease in a Chinese population. PMID: 19853937
CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle PMID: 11799476
results suggest that heterozygous cryptic family 1 (CFC1) mutation may represent a genetic predisposition to biliary atresia splenic malformation syndrome PMID: 18162845
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension is reported. PMID: 18930707

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Involvement in disease

Heterotaxy, visceral, 2, autosomal (HTX2)

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.

Protein Families

EGF-CFC (Cripto-1/FRL1/Cryptic) family

Database Links

HGNC: 18292

OMIM: 605194

KEGG: hsa:55997

STRING: 9606.ENSP00000259216

UniGene: Hs.567542

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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