CKMT1A Antibody

Code CSB-PA09817A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA09817A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA09817A0Rb at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA09817A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CKMT1A Polyclonal antibody
Uniprot No.
Target Names
CKMT1A
Alternative Names
Acidic-type mitochondrial creatine kinase antibody; CKMT antibody; CKMT1 antibody; CKMT1B antibody; Creatine kinase mitochondrial 1 (ubiquitous) antibody; Creatine kinase mitochondrial 1B antibody; Creatine kinase U type mitochondrial antibody; Creatine kinase U-type antibody; KCRU_HUMAN antibody; Mia-CK antibody; mitochondrial antibody; U-MtCK antibody; Ubiquitous mitochondrial creatine kinase antibody; UMTCK antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Creatine kinase U-type, mitochondrial protein (40-417AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CKMT1A Antibody (Product code: CSB-PA09817A0Rb) is Non-conjugated. For CKMT1A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA09817B0Rb CKMT1A Antibody, HRP conjugated ELISA
FITC CSB-PA09817C0Rb CKMT1A Antibody, FITC conjugated
Biotin CSB-PA09817D0Rb CKMT1A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Gene References into Functions
  1. The highly conserved residue E227 acts as the catalytic base to accept the guanidinium proton transferred from creatine in UMTCK. PMID: 27909311
  2. Mitochondrial creatine kinase CKMT1 is necessary for survival of EVI1-expressing cells in subjects with EVI1-positive AML. PMID: 28191887
  3. LRRK2 can interact directly with uMtCK to block its entry into mitochondria and its subsequent processing. PMID: 21370995
  4. CKMT1 is a key regulator of the permeability transition pore through a complex that is distinct from the classical permeability transition pore. PMID: 24522192
  5. mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator PMID: 24174293
  6. The results indicated that uMtCK expression is associated with a poor prognosis in breast cancer and might serve as a tumor marker. PMID: 22982673
  7. Significantly greater creatine kinase carbonylation is associated with chronic obstructive pulmonary disease PMID: 16166745
  8. Because creatine kinase temporally buffers ATP, these observations support the hypothesis that a deficit in myofibrillar energy delivery contributes to chronic heart failure pathophysiology in human left ventricular hypertrophy. PMID: 16952984

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Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein Families
ATP:guanido phosphotransferase family
Database Links

HGNC: 31736

OMIM: 123290

KEGG: hsa:1159

STRING: 9606.ENSP00000406577

UniGene: Hs.654988

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