CLCN4 Antibody

Datasheet

Code	CSB-PA968321
Size	US$297
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Image	Western blot analysis of extracts from MCF-7 cells, using CLCN4 antibody. Immunofluorescence analysis of HUVEC cells, using CLCN4 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLCN4 Polyclonal antibody

Uniprot No.

P51793

Target Names

CLCN4

Alternative Names

Chloride channel 4 antibody; Chloride channel protein 4 antibody; Chloride channel; voltage sensitive 4 antibody; Chloride transporter ClC-4 antibody; ClC 4A antibody; ClC-4 antibody; CLC4 antibody; ClC4A antibody; CLCN4 antibody; CLCN4_HUMAN antibody; H(+)/Cl(-) exchange transporter 4 antibody; MGC163150 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from internal of Human CLCN4.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC,IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:200
IF	1:100-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.

Gene References into Functions

This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
the voltage dependence of uncoupled ClC-4 by protons and anions PMID: 21354396
CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump. PMID: 15057754
coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo PMID: 16034421
crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins PMID: 16176272
A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels. PMID: 19364886
Vesicle acidification, exocytosis, endocytosis, and secretory pathway. PMID: 10564087

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Involvement in disease

Mental retardation, X-linked 49 (MRX49)

Subcellular Location

Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Protein Families

Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily

Tissue Specificity

Abundant in skeletal muscle and also detectable in brain and heart.

Database Links

HGNC: 2022

OMIM: 300114

KEGG: hsa:1183

STRING: 9606.ENSP00000370213

UniGene: Hs.495674

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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