CLIP3 Antibody

Code CSB-PA001708
Size US$119
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  • Western Blot analysis of A549 cells using CLIP3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CLIP3
Alternative Names
1500005P14Rik antibody; AI844915 antibody; CAP GLY domain containing linker protein 3 antibody; CAP-Gly domain-containing linker protein 3 antibody; CLIP 170 related 59 kDa protein antibody; CLIP-170-related 59 kDa protein antibody; clip3 antibody; CLIP3_HUMAN antibody; CLIPR 59 antibody; CLIPR-59 antibody; CLIPR59 antibody; Cytoplasmic linker protein 170 related 59 kDa protein antibody; Cytoplasmic linker protein 170-related 59 kDa protein antibody; Restin like 1 antibody; RSNL1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human CLIP3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
Gene References into Functions
  1. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. PMID: 27613819
  2. CLIPR-59 interacts with Spy1 resulting in its decreased association with a de-ubiquitinating enzyme in glioblastoma cells. PMID: 26017671
  3. CLIPR-59 modulates ubiquitination of RIP1, resulting in the formation of Complex-II and thus promoting Caspase-8 activation to induce apoptosis by TNF-alpha. PMID: 22297296
  4. CLIPR-59 may act as a typical chaperone, allowing a prompt interaction between tubulin and the raft component GD3 during cell apoptosis triggered by CD95/Fas PMID: 20052288
  5. play an important role in membrane-microtubule interactions. PMID: 11854307
  6. CLIPR-59 prevents microtubule-raft interactions PMID: 15262990

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Subcellular Location
Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Database Links

HGNC: 24314

OMIM: 607382

KEGG: hsa:25999

STRING: 9606.ENSP00000353732

UniGene: Hs.466539

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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