CLIP3 Antibody

Code CSB-PA001708
Size US$100
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  • Western Blot analysis of A549 cells using CLIP3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CLIP3
Alternative Names
1500005P14Rik antibody; AI844915 antibody; CAP GLY domain containing linker protein 3 antibody; CAP-Gly domain-containing linker protein 3 antibody; CLIP 170 related 59 kDa protein antibody; CLIP-170-related 59 kDa protein antibody; clip3 antibody; CLIP3_HUMAN antibody; CLIPR 59 antibody; CLIPR-59 antibody; CLIPR59 antibody; Cytoplasmic linker protein 170 related 59 kDa protein antibody; Cytoplasmic linker protein 170-related 59 kDa protein antibody; Restin like 1 antibody; RSNL1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human CLIP3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
Gene References into Functions
  1. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. PMID: 27613819
  2. CLIPR-59 interacts with Spy1 resulting in its decreased association with a de-ubiquitinating enzyme in glioblastoma cells. PMID: 26017671
  3. CLIPR-59 modulates ubiquitination of RIP1, resulting in the formation of Complex-II and thus promoting Caspase-8 activation to induce apoptosis by TNF-alpha. PMID: 22297296
  4. CLIPR-59 may act as a typical chaperone, allowing a prompt interaction between tubulin and the raft component GD3 during cell apoptosis triggered by CD95/Fas PMID: 20052288
  5. play an important role in membrane-microtubule interactions. PMID: 11854307
  6. CLIPR-59 prevents microtubule-raft interactions PMID: 15262990

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Subcellular Location
Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Database Links

HGNC: 24314

OMIM: 607382

KEGG: hsa:25999

STRING: 9606.ENSP00000353732

UniGene: Hs.466539

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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