CLK4 Antibody

Datasheet

Code	CSB-PA129473
Size	US$297
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Image	Western blot analysis of extracts from HT-29 cells, using CLK4 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLK4 Polyclonal antibody

Uniprot No.

Q9HAZ1

Target Names

CLK4

Alternative Names

AI987988 antibody; C85119 antibody; CDC like kinase 4 antibody; CDC-like kinase 4 antibody; CLK4 antibody; CLK4_HUMAN antibody; DKFZp686A20267 antibody; Dual specificity protein kinase CLK4 antibody; OTTMUSP00000005756; antibody; OTTMUSP00000005757 antibody; OTTMUSP00000041113 antibody; Protein serine threonine kinase Clk4 antibody; RP23-9N7.1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human CLK4.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Gene References into Functions

Clk1, Clk2 and Clk4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. PMID: 27126587
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. PMID: 19168442

Subcellular Location

Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily

Tissue Specificity

Expressed in liver, kidney, heart, muscle, brain and endothelial cells.

Database Links

HGNC: 13659

OMIM: 607969

KEGG: hsa:57396

STRING: 9606.ENSP00000316948

UniGene: Hs.406557

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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