CMPK1 Antibody

Datasheet

Code	CSB-PA005616ESR2HU
Size	US$166
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Image	Western blot All lanes: CMPK1 antibody at 3.55µg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 23, 17 kDa Observed band size: 23 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005616ESR2HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CMPK1 Polyclonal antibody

Uniprot No.

P30085

Target Names

CMPK1

Alternative Names

CMK antibody; CMPK 1 antibody; CMPK antibody; cmpk1 antibody; Cytidine monophosphate (UMP CMP) kinase 1 cytosolic antibody; Cytidine monophosphate kinase antibody; Cytidine monophosphate UMP CMP kinase 1 cytosolic antibody; Cytidylate kinase antibody; dCMP kinase antibody; Deoxycytidylate kinase antibody; EC 2.7.4.14 antibody; KCY antibody; KCY_HUMAN antibody; Monophosphatase kinase antibody; OTTHUMP00000009565 antibody; RP11 511I2.1 antibody; UCK antibody; UMK antibody; UMP CMP antibody; UMP CMP kinase antibody; UMP-CMP kinase antibody; UMP/CMP kinase antibody; UMP/CMPK antibody; UMPK antibody; Uridine monophosphate kinase antibody; Uridine monophosphate/cytidine monophosphate kinase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human UMP-CMP kinase protein (37-196AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO uses the recombinant human CMPK1 protein (37-196AA) to immunize rabbits to generate the anti-CMPK1 antibody. The resulting antibody is a polyclonal antibody and exists as an unconjugated IgG. It has undergone antigen affinity purification. It only reacts with human CMPK1 protein, which is required for cellular nucleic acid biosynthesis. This CMPK1 antibody has been validated for use in ELISA, WB, and IHC applications.

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Target Background

Function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Gene References into Functions

Nuclear CMPK1 expression is indicative of poor prognosis in the triple negative breast cancer patients. PMID: 27558661
TGF-b1 inhibited the expression of CMPK, which was blocked in the presence of a TGF-b type I receptor, SB431542, and was abolished by the inhibitor of miR-130b-3p, indicating that CMPK is regulated by the TGF-b signalling pathway through the upregulation of miR-130b-3p. PMID: 28414100
The role of CMP/UMP kinase (CMPK), an enzyme catalyzes cytidine diphosphate formation, in DNA repair, was investigated. PMID: 25659034
CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information PMID: 22838950
Single-nucleotide polymorphisms in CMPK1 gene is associated with treatment response in non-small cell lung cancer. PMID: 21642870
UMP/CMP kinase (EC 2.7.4.14) is not critical for the phosphorylation of CMP, dCMP and maintenance of natural nucleotide pools in cells PMID: 21559290
thymidylate synthase/ribonucleotide reductase gene silencing and deoxycytidine kinase::uridine monophosphate kinase fusion gene gene overexpression markedly improved gemcitabine's therapeutic activity PMID: 19568409
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. PMID: 11912132
UMP/CMP kinase reveals the conformational changes that occur upon substrate binding PMID: 15163660
Models for the phosphorylation action and substrate specificity of human UMP/CMP kinase. PMID: 15550676
Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP PMID: 17608725

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Adenylate kinase family, UMP-CMP kinase subfamily

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 18170

OMIM: 191710

KEGG: hsa:51727

STRING: 9606.ENSP00000360939

UniGene: Hs.731647

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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