CNNM2 Antibody

1. CNNM2 single nucleotide polymorphisms association with the risk of hypertension in Chinese Han population. PMID: 30180964
2. In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT-CNNM2-NT5C2, two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT, while rs11191514 is located in one of the introns of CNNM2. PMID: 27401531
3. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus PMID: 27004590
4. Sensitivity of CNNM2 expression to extracellular Mg(2+) depletion depends on cell type. PMID: 27068403
5. meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations. PMID: 25053769
6. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form. PMID: 25184538
7. Cells expressing mutated CNNM2 proteins did not show increased Mg(2+) uptake. PMID: 24699222
8. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition. PMID: 24311551
9. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri. PMID: 24160291
10. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation PMID: 23027747
11. analysis of structure of CNNM2 and its post-translational modifications PMID: 22399287
12. ACDP2 splice-variant 1 is a functional Mg2+-transporting entity per se. PMID: 20519162
13. The CNNM2 locus is associated with serum Mg(2+) concentrations. PMID: 21397062

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HGNC: 103

OMIM: 607803

KEGG: hsa:54805

STRING: 9606.ENSP00000358894

UniGene: Hs.643509