COL12A1 Antibody

Datasheet

Code	CSB-PA859521LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA859521LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA859521LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COL12A1 Polyclonal antibody

Uniprot No.

Q99715

Target Names

COL12A1

Alternative Names

COL12A1 antibody; COL12A1LCollagen alpha-1(XII) chain antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Collagen alpha-1(XII) chain protein (140-316AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The COL12A1 Antibody (Product code: CSB-PA859521LA01HU) is Non-conjugated. For COL12A1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA859521LB01HU	COL12A1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA859521LC01HU	COL12A1 Antibody, FITC conjugated
Biotin	CSB-PA859521LD01HU	COL12A1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.

Gene References into Functions

The study indicates that the spectrum of causative genes in extracellular matrix-related myopathies be extended to include COL12A1. PMID: 24334769
collagen alpha-1 (XII) chain was expressed at dramatically higher (~10-fold) levels in breast PMID: 24262153
Type XII collagen is overexpressed in permanent human and mouse corneal scars and could represent a new target to treat corneal scarring. PMID: 22969073
In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. PMID: 22573329
COL12A1 is associated with anterior cruciate ligament ruptures among females PMID: 19443461
this study identifies COL12A1 as the likely gene candidate within the recurrent 6q13 breakpoint and provides an alternative approach for detecting 6q13 anomalies in nondividing cells of chondromyxoid fibroma. PMID: 19648885
induction of expression by sheare stress is associated with atherogenesis PMID: 12890494
Results suggest that collagens XII and XIV might serve different functions during human embryonic development although their structures are highly similar. PMID: 15609093

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Involvement in disease

Ullrich congenital muscular dystrophy 2 (UCMD2); Bethlem myopathy 2 (BTHLM2)

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Protein Families

Fibril-associated collagens with interrupted helices (FACIT) family

Tissue Specificity

Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, ki

Database Links

HGNC: 2188

OMIM: 120320

KEGG: hsa:1303

STRING: 9606.ENSP00000325146

UniGene: Hs.101302

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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