CPOX Antibody

1. The monomer form of mutated CPOX did not show any activity and homodimeric enzymes derived from Hereditary coproporphyria (HCP) mutant showed low activity (<20% of the control). PMID: 24078084
2. Polymorphism of coproporphyrinogen oxidase is associated with genetic susceptibility to the adverse neurobehavioral effects of Hg exposure in children. PMID: 22765978
3. Deletion of the fifth exon in the CPOX gene is associated with hereditary coproporphyria. PMID: 21231929
4. CPOX polymorphisms are associated with biological media contamination and apoptosis disorders. PMID: 22288185
5. competitive action of both uroporphyrinogen decarboxylase and CPO on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis PMID: 21277781
6. disease-producing mutations in the CPO gene in nine Swedish families with hereditary coproporphyria PMID: 12181641
7. coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase PMID: 12208494
8. Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using CPO. PMID: 14669009
9. All other type of mutations or missense mutations mapped elsewhere throughout the CPO gene, lead to coproporphyrin accumulation and subsequently typical HCP. PMID: 16159891
10. CPO mutations form the structural basis of hereditary coproporphyria. PMID: 16176984
11. The Km recognition) and Kcat values for coproporphyrinogen III and IV were determined. PMID: 16258391
12. His158 of human CPO may have a role in the active site, but none of the conserved histidine residues of human coproporphyrinogen oxidase is essential for catalytic activity. PMID: 17179900
13. The authors report the association of a novel mutation in the coproporphyrinogen oxidase gene in an Irish pedigree with the devlopment of hereditary coproporphyria PMID: 18557518
14. Three of the novel missense mutations and one frameshift mutation was detected in coproporphyrinogen III oxidase (CPO) gene in five Italian patients affected by Hereditary Coproporphyria (HCP). PMID: 19267996
15. biochemical & kinetic properties of CPOX4, the product of a polymorphism of the CPOX gene that modifies effects of mercury on neurobehavioral function; suggests CPOX4 may predispose to impaired heme biosynthesis which is limited further by Hg exposure PMID: 19339664

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HGNC: 2321

OMIM: 121300

KEGG: hsa:1371

STRING: 9606.ENSP00000264193

UniGene: Hs.476982