CRISP2 Antibody

Code CSB-PA005975ESR1HU
Size US$166
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  • Western blot
    All lanes: CRISP2 antibody at 12μg/ml + Rat gonad tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 28, 32 kDa
    Observed band size: 28 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005975ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CRISP2 Polyclonal antibody
Uniprot No.
Target Names
CRISP2
Alternative Names
Cancer/testis antigen 36 antibody; CRIS2_HUMAN antibody; CRISP 2 antibody; CRISP-2 antibody; CRISP2 antibody; CT36 antibody; Cysteine rich secretory protein 2 antibody; Cysteine-rich secretory protein 2 antibody; GAPDL5 antibody; Glyceraldehyde 3 phosphate dehydrogenase like 5 antibody; Testis specific protein 1 (probe H4 1 p3 1) antibody; Testis specific protein TPX1 antibody; Testis-specific protein TPX-1 antibody; TPX1 antibody; TSP1 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Cysteine-rich secretory protein 2 protein (22-243AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
Gene References into Functions
  1. low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males PMID: 27517483
  2. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. PMID: 27161017
  3. Crisp2 genetic defects in sperm from humans and mice result in male infertility. PMID: 26786179
  4. Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception. PMID: 25505194
  5. Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells. PMID: 23661501
  6. CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins. PMID: 23027975
  7. The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility. PMID: 21485539
  8. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
  9. TPX1 is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction. PMID: 15734896
  10. The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. PMID: 16759931
  11. Polymorphisms within the CRISP2 gene have no significant association with male infertility. PMID: 18550510

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Subcellular Location
Secreted.
Protein Families
CRISP family
Tissue Specificity
Testis and epididymis.
Database Links

HGNC: 12024

OMIM: 187430

KEGG: hsa:7180

STRING: 9606.ENSP00000339155

UniGene: Hs.2042

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