CRTC1 Antibody

1. Pharmacological inhibition of mTORC1 by rapamycin in PHA-stimulated PBL reduced viral replication to the level found in unstimulated lymphocytes, indicating that mTORC1 activity supports MV replication as a proviral host factor. PMID: 29925665
2. SNP located in CRTC1 has been shown in GWAS studies to be significantly associated with the risk of Barrett's esophagus. PMID: 29713984
3. This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1. PMID: 29408765
4. CRTC1 negatively regulates lipogenic gene expression in liver. PMID: 27869139
5. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
6. modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 and MYC activity PMID: 27385002
7. High TORC1 expression is associated with meningioma and schwannoma. PMID: 28729415
8. MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma PMID: 28343305
9. CRTC1 as new mediator of PGE2 signaling PMID: 26300003
10. Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells PMID: 27166823
11. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
12. CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals. PMID: 27002284
13. DNA methylation levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease. PMID: 27094739
14. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC diagnosis but is not associated with differences in survival outcomes. PMID: 26796488
15. A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells. PMID: 26503699
16. Translocation t(11;19)(q14-21;p12-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13. PMID: 24771140
17. This study showed that CREB-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication. PMID: 25300488
18. CRTC1 activation is a key event that drives the LKB1-null mRNA signature in lung cancer. We also identified a positive feedback LKB1/CRTC1 signaling loop for COX-2/PGE2 regulation. PMID: 25465874
19. describe fundamental metabolic requirements of senescent primary human CD8+ T cells and demonstrate that p38 MAPK blockade reverses senescence via an mTOR-independent pathway PMID: 25083993
20. Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein. PMID: 25071166
21. aberrantly activated AREG-EGFR signaling is required for CRTC1-MAML2-positive MEC cell growth and survival, suggesting that EGFR-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC. PMID: 23975434
22. Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression. PMID: 24468654
23. findings suggest that CRTC1 contributes to the genetics of human obesity in psychiatric patients and the general population. PMID: 23925723
24. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
25. The data of this study raise the prospect that CRTC1 plays a role in fundamental aspects of SCN clock timing and entrainment. PMID: 23699513
26. These observations indicate that brain malformations in TSC are likely a consequence of increased TORC1 activation during embryonic brain development. PMID: 22805177
27. CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss. PMID: 23074285
28. We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production. PMID: 22749528
29. Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence. PMID: 22627671
30. The results of this study suggested that CRTC1 dysfunction caused by Abeta accumulation underlies changes in gene expression required for hippocampal-dependent memory in AD transgenic mice. PMID: 22236576
31. Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1. PMID: 22457329
32. de-regulated LKB1-CRTC signaling might represent a crucial mechanism for esophageal cancer progression. PMID: 21706049
33. clear-cell renal cell carcinoma become refractory to REDD1-induced mTORC1 inhibition and shed light into the development of clear-cell renal cell carcinoma PMID: 21798997
34. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
35. The t(11;19) translocation and its CRTC1/MAML1 fusion transcript have been identified in mucoepidermoid carcinomas at different sites and are believed to be associated with the development of a subset of these tumors. PMID: 21074686
36. We report an example of intraosseous mucoepidermoid carcinoma with positive TORC1/MAML2 gene fusion transcript and discuss the clinical implications. PMID: 20625861
37. MECT1/MAML2 translocation status may be important prognostically in salivary mucoepidermoid carcinomas, but it does not seem to override traditional clinicopathologic parameters. PMID: 20588178
38. Data show that somatic loss of LKB1 is associated with underphosphorylation of endogenous Crtc1, enhanced Crtc1 nuclear localization. PMID: 20010869
39. Mucoepidermoid carcinoma (MEC) of the skin harbours CRTC1 rearrangements, a molecular finding that reflects morphological similarities between glandular and cutaneous MEC. PMID: 19438452
40. cloning of a novel fusion gene in mucoepidermoid carcinomas & benign Warthin's tumors; the fusion, which results from a translocation, creates a chimeric gene in which exon 1 of a novel gene designated WAMTP1 is linked to exons 2-5 of MAML2 [WAMPT1] PMID: 14720503
41. mutant Mect1-Maml2 expression plasmid carried silent nucleotide changes within the RNAi target sequence and observed that co-transfection of this mutant, but not wild-type Mect1-Maml2, could partially rescue RNAi growth inhibition in the MEC tumor line PMID: 16652146
42. Thus, both TORC1/2 and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. PMID: 16809310
43. The MECT1-MAML2 fusion transcript may be specific to mucoepidermoid carcinoma and associated with a distinct mucoepidermoid carcinoma subset that exhibits favorable clinicopathologic features and an indolent clinical course. PMID: 16818685
44. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
45. The present and previous observations indicate that the CRTC1-MAML2 fusion is etiologically linked to benign and low-grade malignant tumors originating from diverse exocrine glands rather than being linked to a separate tumor entity. PMID: 17334997
46. CRTC1/MAML2 transcript may be detected in both low and high grade mucoepidermoid carcinoma (MEC), that fusion negative tumors may define a subset of biologically aggressive MEC's tumors PMID: 17437281
47. the basic leucine zipper domain has a role in the regulation of transcriptional activity of CREB with TORC and salt inducible kinase [review] PMID: 17565599
48. CRTC1/MAML2 translocation and fusion transcript is asscociated with Warthin's tumor and mucoepidermoid carcinoma PMID: 18181164
49. The presence of the t(11;19)(q21;p13) rearrangement favors a diagnosis of mucoepidermoid carcinoma. PMID: 18206539
50. Stimulation by lithium of the interaction between CREB and TORC1 is reported. PMID: 18717645

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HGNC: 16062

OMIM: 607536

KEGG: hsa:23373

STRING: 9606.ENSP00000345001

UniGene: Hs.371096