CTDSP2 Antibody

Datasheet

Code	CSB-PA006143GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O14595

Target Names

CTDSP2

Alternative Names

Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody; conserved gene amplified in osteosarcoma 4 antibody; conserved gene amplified in osteosarcoma antibody; CTDS2_HUMAN antibody; Ctdsp2 antibody; NIF2 antibody; NLI interacting factor 2 antibody; NLI-interacting factor 2 antibody; Nuclear LIM interactor interacting factor 2 antibody; Nuclear LIM interactor-interacting factor 2 antibody; OS4 antibody; Protein OS 4 antibody; Protein OS-4 antibody; PSR2 antibody; SCP2 antibody; Small C-terminal domain phosphatase 2 antibody; Small CTD phosphatase 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human CTDSP2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Gene References into Functions

CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras. PMID: 25990325
These results suggest that SCP2 is involved in promoter clearance during steroid-activated transcription. PMID: 16724108
SCP2 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2 PMID: 17085434

Subcellular Location

Nucleus.

Tissue Specificity

Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.

Database Links

HGNC: 17077

OMIM: 608711

KEGG: hsa:10106

STRING: 9606.ENSP00000381148

UniGene: Hs.524530

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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