CWC22 Antibody

Code CSB-PA875721LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA875721LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA875721LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CWC22 Polyclonal antibody
Uniprot No.
Target Names
CWC22
Alternative Names
CWC22 antibody; CWC22 spliceosome associated protein homolog (S. cerevisiae) antibody; CWC22 spliceosome associated protein homolog antibody; CWC22_HUMAN antibody; EIF4GL antibody; fSAPb antibody; Functional spliceosome associated protein b antibody; KIAA1604 antibody; NCM antibody; Nucampholin homolog antibody; Pre-mRNA-splicing factor CWC22 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pre-mRNA-splicing factor CWC22 homolog protein (360-623AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CWC22 Antibody (Product code: CSB-PA875721LA01HU) is Non-conjugated. For CWC22 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA875721LB01HU CWC22 Antibody, HRP conjugated ELISA
FITC CSB-PA875721LC01HU CWC22 Antibody, FITC conjugated
Biotin CSB-PA875721LD01HU CWC22 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Gene References into Functions
  1. The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins. PMID: 24218557
  2. CWC22 connects pre-mRNA splicing and exon junction complex assembly. PMID: 22959432
  3. The essential splicing factor CWC22 has acquired functions in exon junction complex assembly and nonsense-mediated decay during evolution from single-celled to complex eukaryotes. PMID: 23236153
  4. CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly PMID: 22961380
Subcellular Location
Nucleus. Nucleus speckle.
Protein Families
CWC22 family
Database Links

HGNC: 29322

OMIM: 615186

KEGG: hsa:57703

STRING: 9606.ENSP00000387006

UniGene: Hs.311363

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