CYP26A1 Antibody

1. Accumulating evidence suggest that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two neoplastic molecular programs: the retinoid metabolism and Hedgehog pathways. (Review) PMID: 28754309
2. CYP26A1 polymorphisms were associated with increased risk of malignant oral disorders in betel quid chewers. PMID: 25839051
3. CYP26A1-mediated oncogenic characteristics may be partially responsible for the elevated expression of fascin. PMID: 26058854
4. Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents has been described. PMID: 25541526
5. data suggested that CYP26A1 overexpression might contribute to the development and progression of cervical malignancies and squamous neoplasia of the head and neck PMID: 25294402
6. HNF4alpha coordinates with retinoic acid receptors in a retinoic acid-dependent manner to strongly induce CYP26A1 gene expression in the liver, which may explain the high level of response to retinoic acid observed in vivo. PMID: 24819304
7. In liver microsomes, CYP26A1 plays a role in clearing bioactive retinoids. PMID: 25492813
8. CYP26 is able to inactivate retinoids in serum, preventing retinoic acid signaling and thus bone-marrow hematopoietic stem cell differentiation. PMID: 24043786
9. The promoter region of CYP26A1 is significantly hypermethylated in allergic asthmatic subjects. PMID: 21975512
10. Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional vitamin A deficieny state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis PMID: 22179182
11. CYP26A1 and CYP26B1 are qualitatively similar retinoic acid hydroxylases with overlapping expression profiles; CYP26A1 has higher catalytic activity than CYP26B1. PMID: 22020119
12. CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia. PMID: 21850183
13. Primary metabolites of all-trans-retinoic acid formed by CYP26A1 are identified and the ligand selectivity and ligand interactions of CYP26A1 are characterized. PMID: 21521770
14. the functioning of multiple RAREs may account for the strong inducibility of CYP26A1 in liver, which, in turn, may be important physiologically for restoring retinoid homeostasis when the concentration of RA rises. PMID: 20682464
15. CYP26A1 is expressed in human liver microsomes; its expression correlates with retinoic acid hydroxylation. PMID: 20513361
16. The identification of a functional retinoic acid response element located 2.0 kb upstream of the Cyp26A1 transcriptional start site is reported. PMID: 16053444
17. induction and regulation of CYP26A1 expression in human intestinal (Caco-2), liver (HepG2), endothelial (HUVEC), and APL (NB4) cell lines PMID: 16194896
18. Variants in CYP26A1 are unlikely to be a major risk factor for caudal regression syndrome; further study with a larger number of genotyped subjects is required. PMID: 16463413
19. Constitutive expression of CYP26AI in vivo and in organotypic culture was found to be restricted to basal epidermal keratinocytes, as well as eccrine sweat glands and sebaceous glands. PMID: 16778795
20. g.3116delT mutation is of particular interest because it was identified in a patient with spina bifida and likely encodes a truncated protein with no enzymatic activity, as demonstrated by preliminary in vitro data. PMID: 16933217
21. analysis of CYP26A1 active site architecture and ligand binding PMID: 17059167
22. Low CYP26A1 expression may explain high risk of resistance installation, by increase retinoid pressure. PMID: 17218384
23. Three new alleles termed as CYP26A1*2, CYP26A1*3, and CYP26A1*4, are potentially defective in all-trans retinoic acid metabolism. PMID: 17460545
24. Overexpression of CYP26A1 causes intracellular retinoic acid depletion and drives the cell into a highly proliferative and invasive state with induction of other known oncogenes PMID: 18059332
25. Results provide a biochemical framework for CYP26A1 function and offer insight into the role of CYP26A1 as a drug target as well as in fetal development and cell cycle regulation PMID: 18992717
26. cytochrome P450 family 26 (CYP26) enzymes have a role in determining the cellular exposure to retinoic acid by inactivating retinoic acid in cells that do not need retinoic acid--REVIEW PMID: 19519282

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HGNC: 2603

OMIM: 602239

KEGG: hsa:1592

STRING: 9606.ENSP00000224356

UniGene: Hs.150595