CYP39A1 Antibody

Code CSB-PA234598
Size US$297
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  • Western blot analysis of extracts from LOVO cells and HUVEC cells, using Cytochrome P450 39A1 antibody.
  • Immunofluorescence analysis of A549 cells, using Cytochrome P450 39A1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CYP39A1 Polyclonal antibody
Uniprot No.
Target Names
CYP39A1
Alternative Names
24 hydroxycholesterol 7 alpha hydroxylase antibody; 24-hydroxycholesterol 7-alpha-hydroxylase antibody; CP39A_HUMAN antibody; Cyp39a1 antibody; cytochrome P450 family 39; subfamily A polypeptide 1 antibody; Cytochrome P450 39A1 antibody; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1 antibody; Cytochrome P450; family 39; subfamily a; polypeptide 1 antibody; hCYP39A1 antibody; Oxysterol 7 alpha hydroxylase antibody; Oxysterol 7-alpha-hydroxylase antibody; oxysterol 7alpha hydroxylase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human Cytochrome P450 39A1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Gene References into Functions
  1. The CYP39A1 polymorphism rs7761731 may help to identify patients at high risk for treatment related toxicity. PMID: 26475344
  2. GSTA1 and CYP39A1 were found to be associated with busulfan clearance. When combined, the two haplotypes explained 17% of the variability in busulfan clearance. PMID: 24192117
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Liver specific.
Database Links

HGNC: 17449

OMIM: 605994

KEGG: hsa:51302

STRING: 9606.ENSP00000275016

UniGene: Hs.387367

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