CYP39A1 Antibody

Code CSB-PA001977
Size US$100
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  • Western Blot analysis of HeLa cells using CYP39A1 Polyclonal Antibody
  • Western Blot analysis of K562 cells using CYP39A1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CYP39A1
Alternative Names
24 hydroxycholesterol 7 alpha hydroxylase antibody; 24-hydroxycholesterol 7-alpha-hydroxylase antibody; CP39A_HUMAN antibody; Cyp39a1 antibody; cytochrome P450 family 39; subfamily A polypeptide 1 antibody; Cytochrome P450 39A1 antibody; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1 antibody; Cytochrome P450; family 39; subfamily a; polypeptide 1 antibody; hCYP39A1 antibody; Oxysterol 7 alpha hydroxylase antibody; Oxysterol 7-alpha-hydroxylase antibody; oxysterol 7alpha hydroxylase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human CYP39A1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Gene References into Functions
  1. The CYP39A1 polymorphism rs7761731 may help to identify patients at high risk for treatment related toxicity. PMID: 26475344
  2. GSTA1 and CYP39A1 were found to be associated with busulfan clearance. When combined, the two haplotypes explained 17% of the variability in busulfan clearance. PMID: 24192117
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Liver specific.
Database Links

HGNC: 17449

OMIM: 605994

KEGG: hsa:51302

STRING: 9606.ENSP00000275016

UniGene: Hs.387367

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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