DCTN2 Antibody

1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
2. dynamitin is involved in the regulation of Nav1.5 cell-surface density PMID: 25088759
3. the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex PMID: 20463029
4. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. PMID: 14983524
5. the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). PMID: 15580264
6. DCTN2 is required in the earliest stages of peroxisome biogenesis. PMID: 15813749
7. study does not support a major role for DCTN2 overexpression in carcinogenesis PMID: 16369996
8. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. PMID: 18182012
9. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. PMID: 18782227

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HGNC: 2712

OMIM: 607376

KEGG: hsa:10540

STRING: 9606.ENSP00000408910

UniGene: Hs.289123