DEDD2 Antibody

Datasheet

Code	CSB-PA837874ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA837874ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA837874ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DEDD2 Polyclonal antibody

Uniprot No.

Q8WXF8

Target Names

DEDD2

Alternative Names

DEDD2 antibody; FLAME3 antibody; PSEC0004DNA-binding death effector domain-containing protein 2 antibody; DED-containing protein FLAME-3 antibody; FADD-like anti-apoptotic molecule 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Gene References into Functions

FLAME-3 forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898

Subcellular Location

Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.

Tissue Specificity

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell l

Database Links

HGNC: 24450

KEGG: hsa:162989

STRING: 9606.ENSP00000470082

UniGene: Hs.515432

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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