DEPDC1 Antibody

Datasheet

Code	CSB-PA255561
Size	US$166
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Image	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A172 cells, hela cells, hepg2 cells, 293T cells, Primary antibody: CSB-PA255561(DEPDC1 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q5TB30

Target Names

DEPDC1

Alternative Names

5830484J08Rik antibody; Cell cycle control protein SDP35 antibody; DEP domain containing 1 antibody; DEP domain containing protein 1A antibody; DEP domain-containing protein 1A antibody; DEP.8 antibody; DEP1A_HUMAN antibody; DEPDC 1 antibody; DEPDC 1A antibody; DEPDC1 antibody; DEPDC1-V2 antibody; Depdc1a antibody; FLJ20354 antibody; SDP 35 antibody; SDP35 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human DEPDC1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene References into Functions

Our results demonstrated that increased expression of SDP35/DEPDC1A and XPT1/DEPDC1B correlates with metastatic progression of metastatic soft tissue sarcoma PMID: 29297565
The results of this study suggest that DEPDC1 represents a target molecule for the treatment of glioma. PMID: 28555424
DEPDC1a, but not DEPDC1b, was required for the integrity of centrosome and organization of the bipolar spindle PMID: 28602627
DEPDC1 mRNA and protein expression levels were dramatically increased in prostate cancer tissues and cell lines. Overexpression of DEPDC1 promoted, but depletion of DEPDC1 inhibited cell proliferation by regulating the G1-S phase cell cycle transition. PMID: 28634077
miR-130a is an epigenetically regulated miRNA involved in regulation of key molecular and phenotypic features of prostate carcinogenesis, acting as a tumour suppressor miRNA by targeting SEC23B and DEPDC1. PMID: 27984115
Results suggest that protocadherin 10 (PCDH10)-Dishevelled, EGL-10 and Pleckstrin domain containing 1 (DEPDC1)-caspase signaling may be a novel regulatory axis in endometrial endometrioid carcinoma (EEC) development. PMID: 26970279
DEPDC1, plays a pivotal role in the regulation of proper mitotic progression. PMID: 25902835
High DEPDC1 mRNA expression is associated with hepatocellular carcinoma/ PMID: 25605201
DEPDC1 regulates vincristine-induced cell death by promoting JNK-dependent degradation of the BCL-2 family protein MCL1. PMID: 25064737
Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. PMID: 23646139
Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 interacted and colocalized with zinc finger transcription factor ZNF224, a known transcriptional repressor. PMID: 20587513

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Subcellular Location

Nucleus. Note=Colocalizes with ZNF224 at the nucleus.

Tissue Specificity

Expressed in testis. Up-regulated in bladder cancer cells (at protein level).

Database Links

HGNC: 22949

OMIM: 612002

KEGG: hsa:55635

STRING: 9606.ENSP00000412292

UniGene: Hs.445098

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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