DHX58 Antibody

Datasheet

Code	CSB-PA822187ESR1HU
Size	US$166
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Image	Western blot All lanes: DHX58 antibody at 12μg/ml Lane 1: 293T whole cell lysate Lane 2: Rat kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 77 kDa Observed band size: 77 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA822187ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822187ESR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DHX58 Polyclonal antibody

Uniprot No.

Q96C10

Target Names

DHX58

Alternative Names

D11LGP2 antibody; D11lgp2e antibody; DEXH (Asp Glu X His) box polypeptide 58 antibody; DEXH box polypeptide 58 antibody; DHX 58 antibody; DHX58 antibody; DHX58_HUMAN antibody; LGP 2 antibody; LGP2 antibody; Ortholog of mouse D11lgp2 antibody; Probable ATP dependent helicase LGP2 antibody; Probable ATP dependent RNA helicase DHX58 antibody; Probable ATP-dependent helicase LGP2 antibody; Probable ATP-dependent RNA helicase DHX58 antibody; Protein D11Lgp2 homolog antibody; RIG-I-like receptor LGP2 antibody; RLR antibody; RNA helicase LGP2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene References into Functions

Study demonstrated a tumor suppressor role of LGP2 in neuroblastoma (NB). LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients. PMID: 30179292
genetic loss of LGP2 uncovers dsRNA-mediated RNAi albeit less strongly than complete loss of the IFN system PMID: 29351913
Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion. PMID: 28760986
study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity. PMID: 28768856
essential role in activating interferon signaling against hepatitis C virus (HCV) infection by promoting MDA5 recognition of HCV pathogen-associated molecular patterns PMID: 28090671
LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk. PMID: 25288302
LGP2 increases the initial rate of MDA5-RNA interaction and regulates MDA5 filament assembly. PMID: 25127512
results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling PMID: 23184951
LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response PMID: 22837208
Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction. PMID: 22301134
LGP2 functions as an inhibitor of the innate immune response triggered by Rabeis virus infection PMID: 21525357
LGP2 competes with the kinase IKKi for a common interaction site on IPS-1, as an element of negative-feedback regulation of intracellular antiviral signaling. PMID: 17020950
LGP2 can be coexpressed with RIG-I to inhibit activation of the NF-kappaB reporter expression and that LGP2 protein produced in insect cells can bind both single- and double-stranded RNA (dsRNA), with higher affinity and cooperativity for dsRNA. PMID: 18411269
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. PMID: 19278996
Cloning and expression of the mouse Lpg2 mRNA, and comparison of the ORF to that of human LPG2 mRNA. PMID: 11735219

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Subcellular Location

Cytoplasm.

Protein Families

Helicase family, RLR subfamily

Tissue Specificity

Expressed in testis, nerve and spleen. Also expressed in the brain.

Database Links

HGNC: 29517

OMIM: 608588

KEGG: hsa:79132

STRING: 9606.ENSP00000251642

UniGene: Hs.55918

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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