DIS3L Antibody

Code CSB-PA823476LA01HU
Size US$166
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Image
  • Western blot
    All lanes: DIS3L antibody at 6µg/ml + MCF-7 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 121, 106, 87, 112 kDa
    Observed band size: 121 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA823476LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA823476LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DIS3L Polyclonal antibody
Uniprot No.
Target Names
DIS3L
Alternative Names
DIS3L antibody; DIS3L1 antibody; KIAA1955DIS3-like exonuclease 1 antibody; EC 3.1.13.- antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DIS3-like exonuclease 1 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DIS3L Antibody (Product code: CSB-PA823476LA01HU) is Non-conjugated. For DIS3L Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA823476LB01HU DIS3L Antibody, HRP conjugated ELISA
FITC CSB-PA823476LC01HU DIS3L Antibody, FITC conjugated
Biotin CSB-PA823476LD01HU DIS3L Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Gene References into Functions
  1. Data indicate that hDis3L1 is a novel exosome-associated exoribonuclease in the cytoplasm of human cells. PMID: 20531389
  2. Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386
Subcellular Location
Cytoplasm.
Protein Families
RNR ribonuclease family
Database Links

HGNC: 28698

OMIM: 614183

KEGG: hsa:115752

STRING: 9606.ENSP00000321711

UniGene: Hs.446251

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