DIS3L Antibody

Datasheet

Code	CSB-PA823476LA01HU
Size	US$166
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Image	Western blot All lanes: DIS3L antibody at 6µg/ml + MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 121, 106, 87, 112 kDa Observed band size: 121 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA823476LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA823476LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DIS3L Polyclonal antibody

Uniprot No.

Q8TF46

Target Names

DIS3L

Alternative Names

DIS3L antibody; DIS3L1 antibody; KIAA1955DIS3-like exonuclease 1 antibody; EC 3.1.13.- antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DIS3-like exonuclease 1 protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DIS3L Antibody (Product code: CSB-PA823476LA01HU) is Non-conjugated. For DIS3L Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA823476LB01HU	DIS3L Antibody, HRP conjugated	ELISA
FITC	CSB-PA823476LC01HU	DIS3L Antibody, FITC conjugated
Biotin	CSB-PA823476LD01HU	DIS3L Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Gene References into Functions

Data indicate that hDis3L1 is a novel exosome-associated exoribonuclease in the cytoplasm of human cells. PMID: 20531389
Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386

Subcellular Location

Cytoplasm.

Protein Families

RNR ribonuclease family

Database Links

HGNC: 28698

OMIM: 614183

KEGG: hsa:115752

STRING: 9606.ENSP00000321711

UniGene: Hs.446251

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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